摘要
目的探讨食管癌组织P53蛋白的过度表达与肿瘤生物学行为及预后的关系。方法应用单克隆抗P53抗体对28例食管癌组织石蜡标本进行免疫组化染色。结果P53蛋白阳性物质位于肿瘤细胞核内,28例食管癌病例中有16例P53基因表达阳性(57%),与正常食管组织和癌旁组织比较,差异有显著性(P<0.05),且阳性率随分化程度的降低而升高(P<0.05)。结论P53基因的异常表达在食管癌的发展过程中起重要作用,对食管癌患者的预后判断有一定意义。
Objective To investigate expression of P 53 in esophageal cancer tissues and their relationship with tumorous biologic behaviour and prognosis. Methods 28 paraffin embedded samples of esophageal cancer tissues were used immunohistochemical staining by monoclonal P 53 antibody. Results The P 53 lay in the tumor cell nucleus. The rate of positive expression of P 53 is 57% (16/28) which differed significantly from normal esophageal tissue and cancer adjacenttissue (P<0.05). The positive rate was higher while differentiation degree was lower(P<0.05). Conclusion The abnormal expression of P 53 are involved in the progression of esophageal cancer. It may be regarded as marker for predict prognosis of esophageal cancer patients.
出处
《浙江临床医学》
2005年第6期563-564,共2页
Zhejiang Clinical Medical Journal
基金
温州市科委基金资助(2002A031)
