摘要
目的：为深入探讨云锡矿工肺癌高发的发病机理，找寻早期诊断的方法和理论依据。方法：应用免疫组化方法对云锡矿工肺癌41例（M组）、非云锡地区非矿工人群肺癌25例（NM组）和正常肺组织15例（C组）进行p53检测比较研究。数据用四格表确切概率法进行组间显著性测验。结果：发现p53阳性率M组为60．98％，NM组为36％，C组为几三组间差异有高度显著性（P＜0．0），M组与NM组亦有显著差异（P＜0．05），且M组与NM组间鳞癌的p53阳性存在显著差异（0．05＜P＜0．10）。结论：说明突变型p53在肺癌中发生频率高，云锡矿粉特殊性致癌因素可较多地导致p53突变，这也是云锡矿工肺癌中鳞癌多见的可能原因之一。肺癌周围增生支气管粘膜上皮和11型肺泡上皮出现p53阳性，提示增生上皮已有p53突变存在，值得引起注意。
Purpse:To search the pathogenesis of lung carcinoma in Yunnan Tin Mine and looking for early diagnosis method. Methods:The p53 protein were studied in 41 cases of Yunnan Tin miner's lung carcinoma(Group M), 25 cases of lung carcinoma in other regions(Group NM), and 15 cases of normal lung tissue (Group C), with immunohistochemistry method. Results:The result shows that positive rate of p53 was 60. 98% in Group M, 36.00% in Group NM and 0. 00% in Group C, respectively. There is a significant difference between Group M and Group NM (P<0.05). In addition, a significant difference is also identified in comparison of squamous cell carcinoma between these two groups. (0.05<P<0.10). Conclusion:It suggests that p53 mutation is common in lung carcinoma,and the special carcinogenesis factors of Yuman Tin mine's dust may results in p53 mutation more frequently.It might be an explanation why the squamous cell carcinoma make up the majority of Yunnan Tin miner's lung carcinoma.An interesting finding is that positive of p53 in hyperplastic epithelial cells of bronchial mucosas and alveolar type II around carcinoma of the lung. Whether it is an indicator of the early lung carcinoma?It is worth to study farther.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第1期42-44,共3页
Chinese Journal of Cancer
基金
云南省自然科学基金!94C049M
关键词
肺肿瘤
矿工
P53基因
基因突变
Lung carcinoma, Yunnan Tin miner, p53, Immunohistochemistry
