摘要
局部侵袭和远处转移是影响肿瘤预后的主要因素,寻找与肿瘤细胞迁移运动有关的基因,有助于揭示肿瘤转移的分子机制,为肿瘤的治疗提供新的方法和理论依据。Cripto-1在正常组织中不表达或低表达,而在肿瘤组织中高表达;且与肿瘤侵袭和转移密切相关。该文就Cripto-1与肿瘤的发生、发展做一综述。
Local invasion and distant metastasis are the main factors influencing the prognosis of cancer. Looking for the gene related to invasion, not only would indicate the mechanism on tumor metastasis, but also would provide a new method and theoretical basis for the treatment of tumors. Cripto-1 was expressed at low levels in normal tissues, while cripto-1 mRNA or protein were elevated in several dif ferent types of human tumors. Furthermore, Cripto-1 was associated with the invasion and metastasis of tumor. This article is mainly on the relationship between cripto-1 and tumor＇s occurrence and development.
出处
《安徽医药》
CAS
2013年第10期1647-1649,共3页
Anhui Medical and Pharmaceutical Journal
基金
国家自然科学基金资助项目(No 81102678)
