摘要
阿齐霉素片经硫酸显色后采用分光光度法测定其溶出度，测定波长４８２ｎｍ；线性范围：１０～９０μｇ／ｍｌ（ｎ＝５，ｒ＝０．９９９２）；平均回收率９９．４％（ＲＳＤ＝２．３０％）。溶出度用转篮法测定，转速１００ｒ／ｍｉｎ；溶出介质ｐＨ６．０磷酸盐缓冲液，４５ｍｉｎ的累积溶出度大于９０％，不同批号阿齐霉素片溶出度测定结果重现性良好。
Determination of
AMT's dissolution by spectrophotometry which reacted with sulfuric acid at 482nm, rotation
method was used to study the dissolution, the rotative speed was 100 rpm/min and the
solvent was 900ml of pH6.0 phosphate buffer. The linear range of standard curve was 10￣90
μg/ml (r=0.9992, n=5 ). The average recovery of assay was 99.4%( RSD =2.3%). The
accumulative release rate was higher than 90% in 45min, the dissolution profiles were found to
be very good for different batches of AMT.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1999年第1期60-61,共2页
West China Journal of Pharmaceutical Sciences
关键词
阿齐霉素片
溶出度
分光光度法
测定
Azithromycin tablet(AMT) Dissolution
Spectrophotometry
