摘要
目的:评价可降解高分子材料聚丙交酯-乙交酯(PLGA)作为支架药物载体的可行性及携带雷帕霉素的PLGA涂层支架的抗内膜增生作用。方法:在14头微型猪的3支冠状动脉分别植入钴铬合金裸支架(CoCr-BMS)、不载药的PLGA涂层支架(PCOS)和PLGA涂层雷帕霉素洗脱支架(PLGA-SES)。分别在支架植入后1个月和3个月时,复查冠状动脉造影,然后分离支架段血管行组织病理学分析。结果:共有12头动物存活,其余2头动物可能因麻醉剂相关的呼吸抑制而死亡。支架植入后1个月和3个月,不载药的PLGA涂层支架新生内膜面积和晚期管腔丢失与CoCr-BMS组相近,而PLGA-SES组则明显低于CoCr-BMS组。组织形态学示3组支架段血管损伤积分、炎症积分及再内皮化积分差异无统计学意义。结论:在猪冠状动脉支架模型中,PLGA涂层的支架设计具有良好的生物相容性和安全性;携带雷帕霉素的这种支架可抑制新生内膜形成,预防支架再狭窄的发生。
Objective：The purpose of this study was to assess biocompatibility and effect on coronary stenosis of the novel sirolimus-eluting,PLGA coated cobalt-chromium stents in porcine coronary arteries after stent implantation. Methods： A total of 42 stents were deployed in multiple difference coronary arteries of fourteen minipigs including cobalt-chromium bare metal stents （CoCr-BMS,n = 14）,PLGA-coated-only stents （PCOS,n = 14）,and PLGA-based sirolimus-eluting stents （ PLGA-SES,n = 14）. Animals underwent angiographic restudy and were terminated at 1 and 3 months for complete histopathologic and histomorphometric analyses. Results：Twelve minipigs remained well throughout the study,six of which were sacrificed after 1 and 3 months,respectively. The unexpectedly lost two animals might be died of respiratory disturbance induced by anesthetics during the period of perioperation. Histological analysis showed PLGA-coated stents with acceptable performance characteristics in comparison with historical data with CoCr-BMS. PLGA-SES,the novel-generation sirolimus-eluting stent,showed significant reductions in the mean neointimal area and percent area stenosis compared with the CoCr-BMS at 1 and 3 months. Conclusion：In the porcine coronary model,stent-based delivery of sirolimus via a biodegradable PLGA matrix is of better biocompatibility and effectively reduces neointimal hyperplasia within stented segments.
出处
《心肺血管病杂志》
CAS
2010年第4期333-337,共5页
Journal of Cardiovascular and Pulmonary Diseases
关键词
可降解聚合物
药物洗脱支架
再狭窄
血管内膜增生
Biodegradable polymer
Drug-eluting stent
Restenosis
Vascular intimal hyperplasia
