期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

百草枯暴露致帕金森病的机制研究进展 被引量：8

原文传递
导出
摘要 帕金森病（Parkinson’s disease,PD）是中老年人常见的慢性中枢神经系统椎体外系退行性疾病,以静止性震颤、肌肉强直、运动迟缓以及平衡功能障碍为主要临床特征，可伴有记忆力减退、抑郁等精神障碍。欧美国家55岁以上人群的PD患病率为1％；
作者 娄丹 常秀丽 周志俊
机构地区 复旦大学公共卫生学院教育部公共卫生安全重点实验室
出处 《毒理学杂志》 CAS CSCD 北大核心 2010年第3期241-244,共4页 Journal of Toxicology
关键词 帕金森病(PD) 百草枯 神经毒性 动物模型
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献26

  • 1Rajput AH. Frequency and cause of Parkinson's disease [J]. NeurolSci, 1992,19:103-107.
  • 2Zhang Z. Parkinson' s disease in China: prevalence in Beijing, Xi'an, and Shanghai [ J ]. Lancet, 2005,365 : 595- 597.
  • 3Mukaetova-Ladinska EB, McKeith IG. Pathophysiology of synuclein aggregation in Lewy body disease [ J ]. Mech Ageing Dev, 2006,127 : 188-202.
  • 4Tanner CM, Ottman R, Goldman SM, et al. Parkinson disease in twins: an etiologic study[ J]. Am Med Assoc, 1999,281:341-346.
  • 5Spillantini MG, Sehmidt ML, Lee VM, et al. Alpha-synuclein in Lewy bodies[ J]. Nature, 1997,388:839-840.
  • 6Dinis-Oliveira RJ, Remiao F, Carmo H, et al. Paraquat exposure as an etiological factor of Parkinson' s disease [ J ]. Neuro Toxicology, 2006, 27 : 1110-1122.
  • 7Vanacore N, Nappo A, Gentile M, et al. Evaluation of risk of Parkinsons disease in a cohort of licensed pestieide users[ J ]. Neurol Sci, 2002,23 : S119-120.
  • 8Fall PA, Fredrikson M, Axelson O, et al. Nutritional and occupational factors influencing the risk of Parkinson' s disease : a case-control study in southeastern Sweden [ J ]. Mov Disord, 1999,14:28-37.
  • 9Priyadarshi A, Khuder SA, Schaub EA, et al. Environmental risk factors and Parkinson's disease: a meta analysis[ J]. Environ Res, 2001,86(2) :122-127.
  • 10Liou HH, Tsai MC, Chen CJ, et al. Environmental risk factors and Parkinsons disease: a case-control study in Taiwan[ J ]. Neurology, 1997,48 : 1583-1588.

二级参考文献20

  • 1Perez V, Unzeta M. PF 9601N [N-(2-propynyl) -2-(5-benzyloxy-indolyl )methylamine], a new MAO - B inhibitor,attenuates MPTP - induced depletion of striatal dopamine levels in C57/BL6 mice. Neurochem Int,2003,42(3) :221 - 229.
  • 2Bezard E, Gross CE, Fourier MC, et al. Absence of MPTP- induced neuronal death in mice lacking the dopamine transporter. Exp Neurol,1999,155(2) :268 - 273.
  • 3Staal RG, Hogan KA, Liang CL, et al. In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2) : rat versus mouse differences in sequestration of 1-methyl -4-phenylpyridinium. J Pharmacol Exp Ther, 2000, 293(2) :329 - 335.
  • 4Marey - Semper I, Gelman M, Levi - Strauss M. A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation. J Neurosci, 1995, 15(9) :5912 - 5918.
  • 5Leret ML, San Millan JA, Fabre E, et al. Deprenyl protects from MPTP-induced Parkinson - like syndrome and glutathione oxidation in rat striatum. Toxicology, 2002,170(3) : 165 - 171.
  • 6Klivenyi P, Andreassen OA, Ferrante RJ, et al. Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate,3 - nitropropionic acid, and 1-methyl -4-phenyl-1,2, 5,6-tetrahydropyridine. J Neurosci, 2000, 20(1) : 1 - 7.
  • 7Andreassen OA, Ferrante RJ, Dedeoglu A, et al. Mice with a partial deficiency of manganese supemxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. Exp Neurol, 2001, 167(1) :189 - 195.
  • 8Kunikowska G, Jenner P. Alterations in m - RNA expression for Cu, Zn-superoxide dismutase and glutathione peroxidase in the basal ganglia of MPTP - treated marmosets and patients with Parkinson' s disease.Brain Res, 2003, 968(2) :206 - 218.
  • 9Kurosaki R, Muramatsu Y, Michimata M, et al. Role of nitric oxide synthase against MPTP neurotoxicity in mice. Neurol Res, 2002, 24(7) :655 - 662.
  • 10Dehmer T, Lindenau J, Haid S, et al. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem,2000, 74(5) :2213 - 2216.

共引文献8

同被引文献120

引证文献8

二级引证文献25

毒理学杂志
2010年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部