摘要
目的观察"救逆通瘀汤"对心肺复苏后脑保护作用的治疗效果。方法 59例患者分为标准治疗组(29例)和中药干预组(30例),分别采取常规治疗方法和常规方法加"救逆通瘀汤"中药治疗,比较复苏后两组患者6、24、72h、7d的APACHEⅡ评分;72h的CRP、IL-8,IL-6浓度;1个月的存活率和格拉斯哥预后评分。结果复苏后72h〔(18.4±11.3)VS(14.7±6.9)〕和7d〔(16.7±6.6)VS(11.7±4.2)〕APACHEⅡ评分差异有统计学意义(P<0.05);中药干预治疗后72h两组患者CRP〔(132.6±46.7)mg/LVS(56.4±23.1)mg/L〕、IL-8〔(98.1±24.7)pg/mlVS(36.4±11.6)pg/ml〕,IL-6〔(357.2±134.9)pg/mlVS(116.8±54.3)pg/ml〕浓度差异均有统计学意义(P<0.05);1月后两组患者存活率(24.1%VS50.0%)及格拉斯哥预后评分〔(2.9±0.8)VS(3.4±0.9)〕比较差异均有统计学意义(P<0.05)。结论救逆通瘀汤在早期即可抑制复苏后的脑缺血再灌注损伤及其继发的全身炎症反应,提高存活率,改善患者神经功能。
Objective To observe the healing efficacy of Jiunitongyu decoction in Cerebral protection cation for patients after cardio-pulmonary resuscitation（CPR）.Methods 59 of patients after CPR were divided into two groups（standard treatment group and Chinese mdedicie group）.Patients（29 of 59）in standard treatment group were treated with general methods;patients（30 of 59）in Chinese mdedicie group were treated with Jiunitongyu decoction basic general methods.Acute phsiology and chronic health evaluation Ⅱ（APACHE Ⅱ）scores of patients on 6 hours,24 hours,72 hours,7 days,1 month were compared in two groups respectively.Concentration of CRP、IL-8,IL-6 of patients on 72 hours;Survivor rate and Glasgow outcome scale（GOS）on 1 month were also compared respectively.Results Comperd between standard treatment group and Chinese mdedicie group,there had significantly difference in APACHE Ⅱ score on 72 hours〔（18.4±11.3）VS（14.7±6.9）,P0.05〕 and 7days〔（16.7±6.6）VS（11.7±4.2）,P0.05〕;in concentration of CRP〔（132.6±46.7）mg/L VS（56.4±23.1）mg/L,P0.05〕,IL-8〔（98.1±24.7）pg/ml VS（36.4±11.6）pg/ml,P0.05〕,IL-6〔（357.2±134.9）pg/ml VS（116.8±54.3）pg/ml,P0.05〕of patients on 72 hours;in Survivor rate（24.1% VS 50.0%,P0.05）and Glasgow outcome scale〔（2.9±0.8）VS（3.4±0.9）,P0.05〕 on 1 month.Conclusion Jiunitongyu decoction can promote the cerebral function reinstate in patients after CPR,and evaluate survivor rate and quality of life.
出处
《实用心脑肺血管病杂志》
2010年第6期702-704,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
心肺复苏
脑缺血再灌注损伤
APACHEⅡ评分
格拉斯哥预后评分
预后
Cardiopulmonary resuscitation
Cerebral ischemia-reperfusion injury
Acute phsiology and chronic health evaluation Ⅱ
Glasgow outcome scale
Outcome
