摘要
【目的】探讨参附注射液治疗对复苏后多器官功能障碍综合征(PR-MODS)患者心肝肾功能及预后的影响。【方法】50例复苏后MODS患者,随机分为两组,各25例,对照组患者基础治疗,观察组在对照组基础上给予参附注射液治疗;比较两组治疗前后的血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、丙氨酸氨基转移酶(ALT)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、血肌酐(SCr)以及pH值、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、氧合指数(OI)和病死率。【结果】治疗前两组患者上述指标相比较差异均无显著性(P>0.05);治疗后观察组患者的TNF-α、IL-6、ALT、CK、CK-MB、LDH水平均低于对照组(P<0.05);观察组患者的PaCO2水平低于,pH值、PaO2、OI水平均高于对照组(P<0.05);观察组患者的存活率为56.00%(14/25),明显高于对照组的28.00%(7/25),且两组比较差异有显著性(P<0.05)。【结论】参附注射液治疗对复苏后MODS患者的心肝肾功能具有一定的保护作用,可减轻炎症反应损伤,改善患者血气指标,有利于救治成功。
【Objective】To investigate the protective effect of Shenfu injection on the heart,live and kidney function of patients with multiple organ dysfunction syndrome(MODS)after cardiopulmonary resuscitation.【Methods】A total of 50 patients with MODS after resuscitation were randomly divided into two group with 25 cases each.The basic treatment was consistent between the two groups.Simultaneous administration of Shenfu injection was applied in patients of the observation group.Levels of serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),alanine aminotransferase(ALT),creatine kinase(CK),creatine kinase Isoenzyme(CK-MB),lactate dehydrogenase(LDH),blood creatinine(SCr),pH value,arterial blood oxygen partial pressure(PaO2),arterial blood carbon dioxide partial pressure(PaCO2),oxygenation index(OI)and mortality before and after treatment were compared in the two groups.【Results】There were no significant differences in all detected parameters between the two groups of patients before treatment(P>0.05).After treatment,the levels of TNF-α,IL-6,ALT,CK,CK-MB and LDH in the observation group were lower than those in the control group(P<0.05).Before treatment,the differences in pH,PaO2,PaCO2 and OI levels between two groups were not statistically significant(P>0.05).However,after treatment,the PaCO2 level of the observation group was lower and the pH value,PaO2 and OI levels in the observation group were higher than those in the control group(P<0.05).The patient survival rate of the observation group was 56.00%(14/25),which was higher than that of the control group(28.00%,7/25).The difference was statistically significant(P<0.05).【Conclusion】Shenfu injection for the treatment of patients with MODS after resuscitation has certain protective effects on heart,liver and kidney function.It reduces inflammatory reactive damage and improves blood gas index of patients.
作者
王一如
芮庆林
WANG Yi-ru;RUI Qing-lin(Jiangsu Provincial Hospital of Traditional Chinese Medicine.Nanjing,Jiangsu.210001)
出处
《医学临床研究》
CAS
2019年第12期2376-2378,共3页
Journal of Clinical Research
