摘要
目的观察血必净对心肺复苏（CPR）后复苏后综合征（PRS）的防治作用。方法经标准心肺复苏自主循环恢复（ROSC）后存活期≥7d的患者41例，随机分为血必净治疗组（19例）和对照组（22例）。血必净治疗组加用血必净注射液50ml静脉滴注（静滴），每天2次，连续7d，余治疗措施两组相同。观察并记录ROSC当天和7d后的心率、血压、是否有消化道出血，测定中心静脉压、动脉血氧分压（PaO2）、血肌酐（SCr）、总胆红素（TBil）、血小板（PLT），行格拉斯哥评分（GCS），结合上述指标进行Marshall氏评分，判断发生功能障碍的器官数耳及程度，统计PRS的发生率、28d存活率等。结果治疗7d后，治疗组PRS发生率为57．9％，显著低于对照组（68．2％，P〈0．01）；治疗组器官功能障碍数为（2．4±1．1），显著少于对照组（3．6±2．1，P〈0．01）；治疗组Marshall氏评分为（3．5±1．7），显著低于对照组[（4．8±2．2），P〈0．01]；治疗组28d存活率为63．2％，显著高于对照组（45．5％，P〈0．01）。结论血必净能有效降低CPR后PRS的发生率，减少脏器衰竭数目及程度，提高存活率。
Objective To observe the preventive and therapeutic effects of Xuebijing to post-resuscitation syndrome （PRS） after cardiopulmonary resuscitation （CPR）. Methods Forty-one patients successfully surviving for ≥7d after CPR and restoration of spontaneous circulation （ROSC） were randomly divided into 2 groups： control group （n=22） undergoing conventional treatment, and Xuebijing group （n=19） undergoing intravenous drip infusion of Xuebijing 50 ml twice a day for 7d in addition to the conventional treatment. Heart rate （HR）, blood pressure （BP）, alimentary tract hemorrhage, central venous pressure （CVP）, partial pressure of oxygen （PaO2）, serum creatinine （SCr）, total bilirubin （TBil）, platelet （PLT）, Glasgow coma score （GCS） were observed on the first and seventh days after ROSC respectively. Multiple organ dysfunction score （Marshall＇ s score）, number and degree of dysfunctional organs, PRS rate, and 28d survival rate were calculated. Results Seven days after the treatments, the PRS rate of the Xuebijing group were 57.9%, significantly lower than that of the control group （68.2%, P〈0.01）. The number of dysfunctional organs of the Xuebijing group was （2.4±1.1）, significantly lower than that of the control group [（3.6±2.1）, P〈0.01]. The Marshall＇ score of the Xuebijing group was （3.5±1.7）, significantly lower than that of the control group [（4.8±2.2）, P〈0.01]. The 28 d survival rate of the Xuebijing group was 63.2%, significantly higher than that of the control group （45.5%, P〈0.01）. Conclusion Xuebijing effectively lowers the PRS rate after CPR, decreases the number and degree of involved organs, and thereafter increases the survival rate.
出处
《中国急救复苏与灾害医学杂志》
2009年第6期381-383,共3页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
血必净
心肺复苏
复苏后综合征
Xuebijing
Cardiopulmonary resuscitation
Post-resuscitation syndrome
