摘要
目的:探讨一氧化氮(NO)在肝硬化患者及慢性肝炎患者门静脉系统中的作用。方法:采用硝酸还原酶法检测20例肝硬化组,20例慢性肝炎组及10例正常对照组患者门静脉血及外周静脉血浆中iNOS活力。结果:在慢性肝炎患者及肝硬化患者门静脉血与外周血中iNOS活力与对照组相比均明显升高,且门静脉血iNOS活力升高更为明显。结论:iNOS/NO体系在肝硬化发生发展中起着保持血管舒张状态的重要作用。
Objective： To study the effect of NO in the course in which hyperdynamic circulation with hepatic cirrhosis occurs in patients with chronic hepatitis patients and liver cirrhosis patients.Methods：The plasma NO activity was measured with colorimetric analysis including the group of chronic hepatitis（n=20）,the group of liver cirrhosis（n=20） and the group of control（n=10）.Results： The plasma iNOS activity in portal venous and peripheral with chronic hepatitis and cirrhosis patients are all increased than it is in control group.Furthermore,the iNOS activity in portal venous was more visible increased.Conclusion：iNOS/NO system has an important effect which maintains the state of diastolic blood vessels on the occurrence and development with hepatic cirrhosis.
出处
《农垦医学》
2009年第6期501-503,共3页
Journal of Nongken Medicine
基金
石河子大学医学院基础与临床医学联合科研基金项目(项目编号:LHJJ00608)
关键词
肝硬化
慢性肝炎
门静脉和下腔静脉血
诱导型一氧化氮合成酶
chronic hepatitis
hepatic cirrhosis
portal vein and inferior vena cava
nitric oxide inducible nitric oxide synthase
