摘要
目的:探讨瑞芬太尼复合丙泊酚静脉麻醉在经眶上锁孔入路切除鞍区巨大肿瘤中的应用。方法:42例鞍区巨大肿瘤均行经眶上锁孔入路切除手术,随机分为2组,A组行瑞芬太尼复合丙泊酚持续泵注维持麻醉;B组行芬太尼复合丙泊酚持续泵注维持麻醉。分别记录2组平均动脉压、心率、呼气末二氧化碳分压、苏醒参数(睁眼时间、自主呼吸恢复时间、拔管时间)及术后并发症情况。结果:2组患者的麻醉过程平稳,均能顺利完成手术,麻醉效果满意。无1例术后出现麻醉相关并发症。但A组在插管后和拔管后血压、心率的变化小于B组(P<0.05);各项苏醒参数也优于B组(P<0.05)。结论:与芬太尼比较,瑞芬太尼复合丙泊酚静脉麻醉,诱导时间更短,麻醉维持期血流动力学更稳定,清醒快而完全,更适于经眶上锁孔入路鞍区巨大肿瘤切除手术。
OBJECTIVE：To study the application of remifentanil and propofol-inducing intravenous anesthesia in transsupraorbital keyhole approach for the resection of giant pituitary adenomas. METHODS：42 patients with giant tumors in sellar region were randomized into 2 groups. Patients of 2 groups were intubated in respiration tract after intravenous anesthesia. Anesthesia was maintained with either remifentanil combined with propofol （group A） or fentanyl combined with propofol （group B） with continuous infusion. Mean arterial blood pressure, heart rate, end-tidal carbon dioxide partial pressure situation, wake parameters （eyes open time, self-breathing recovery time, extubation time） and postoperative complications were recorded. RESULTS：The symptoms of patients during anesthesia kept steady. Operation and anesthetic effect were completed. There were no relevant complication after operation. The change of blood pressure and heart rate in group A after intubation and extubation were all less than in group B （P0.05）. The wake parameters in group A were also better than in group B （P0.05）. CONCLUSION： Intravenous anesthesia induced by remifentanil combined with propofol is better than fentanyl for shortening induction time, stabilizing hemodynamics, increasing waking speed for transsupraorbital keyhole approach for the resection of giant pituitary adenomas.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第20期1856-1857,共2页
China Pharmacy
关键词
瑞芬太尼
丙泊酚
鞍区巨大肿瘤
麻醉
Remifentanil
Propofol
Giant pituitary adenomas in sellar region
Anesthesia
