摘要
目的:研究丙泊酚用于神经外科全身麻醉手术患者的药动学。方法:8名神经外科全身麻醉手术患者静脉注射丙泊酚2mg·kg-1后,用高效液相色谱法测定血清中丙泊酚的浓度。用3p97程序拟合计算药动学参数。结果:静脉注射丙泊酚后的药-时曲线符合三室模型;主要药动学参数t1/2α、t1/2β、t1/2γ分别为(0·8±0·41)、(10·2±15·6)、(113·0±47·2)min,Vc、Vd分别为(0·0548±0·0218)、(2·6482±0·6638)L·kg-1,CL为(17·4±4·5)mL·min-1·kg-1,AUC0～∞为(108·92±31·68)mg·min·L-1。结论:丙泊酚的药动学特征与临床麻醉中迅速分布于全身、起效快、作用时间短、苏醒恢复迅速等特点一致。
OBJECTIVE： To study the pharmacokinetics of propofol in neurosurgical patients undergoing general anesthesia.METHODS： 8 neurosurgical patients undergoing general anesthesia were assigned to receive propofol iv（2m ·kg^-1）, with their serum concentration of propofol determined by HPLC and pharmacokinetic parameters processed with 3P97 program. RESULTS： The serum concentrationtime curve was in line with three compartment model .The pharmacokinetic parameters were the following： tl/2α, t1/2β and t1/2γ were （0.8± 0.41）, （10.2± 15.6） and （113.0± 47.2）min, respectively; Vc and Vd were （0.054 8±0.021 8） and （2.648 2±0.663 8） L · kg^-1, respectively; CL was（17.4±4.5） mL · min^-1·kg^-1 and AUC0-∞ was （108.92± 31.68） mg · min · L^-1.CONCLUSION： Similar to that manifested in clinical anesthesia, the pharmacokinetics of propofol are characterized by rapid distribution throughout body, rapid onset, short duration of action and rapid recovery of consciousness etc.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第14期1066-1067,共2页
China Pharmacy
基金
全军医学科学技术研究"十一五"计划科技攻关课题资助项目(06G023)
