摘要
为观察急性胆管炎时脂质过氧化损害情况，以及维生素Ｅ（ＶＥ）乳剂对肝脏功能的保护作用，采用大鼠急性胆管炎模型，于模型制作时及制作后２４小时经肠系膜静脉注入ＶＥ乳剂或空白乳剂，并于制作后４８小时活杀动物，取肝脏组织及血清检测丙二醛（ＭＤＡ）含量、超氧化物歧化酶（ＳＯＤ）活性及三磷酸腺苷（ＡＴＰ）含量。结果：与空白乳剂组比较，ＶＥ乳剂组肝组织及血清中ＭＤＡ和线粒体谷草转氨酶均显著降低（Ｐ＜０．０５），ＳＯＤ活性显著升高（Ｐ＜０．０５）；感染肝叶肝脏组织ＡＴＰ含量亦显著高于空白乳剂组（Ｐ＜０．０５）。本实验结果提示：静脉输注大剂量ＶＥ乳剂可明显减轻急性胆管炎时的脂质过氧化反应。
To study the lipid peroxidation injury and the protecting effect of vitamin E emulsion on liver function following acute cholangitis. During the operation and 24 hours after operation, vitamin E emulsion or placebo emulsion was infused via mesenteric vein in rats suffering acute cholangitis. The contents of malondialdehyde (MDA), superoxide dismutase (SOD) and adenosine triphosphate (ATP) in the liver tissue and serum were measured at 48hrs after operation. Results: As compared with the placebo emulsion group, MDA and m GOT contents in the liver tissue and serum decreased significantly, but SOD activity increased dramatically in the VE emulsion group. ATP content in the infected lobe was much higher than those in the placebo emulsion group. Conclusion: Intravenous infusion of large dose of vitamin E emulsion may reduce the lipid peroxidation reaction in acute cholangitis, and have protecting effect.
出处
《中国普外基础与临床杂志》
CAS
1999年第2期68-69,共2页
Chinese Journal of Bases and Clinics In General Surgery
