摘要
为分析实验性胆原性脓毒症时动脉血酮体比（ＡＫＢＲ）与肝脏能量代谢改变之间的关系，借助兔自身对照性动物模型，对胆原性脓毒症状态下肝脏线粒体呼吸功能、肝组织ＡＴＰ含量及ＡＫＢＲ进行了动态检测。自术后１２ｈ起，感染肝叶线粒体Ｓ３和ＲＣＲ呈进行性显著降低。非感染肝叶线粒体ＲＣＲ呈先升后降的双相改变。感染和非感染肝叶组织内ＡＴＰ含量与其线粒体呼吸活性同步降低。在术后１２ｈ，尽管非感染肝叶线粒体呼吸活性增强而处于代偿状态，ＡＫＢＲ已伴随感染肝叶ＲＣＲ降低而显著减低，并随病程延续呈进行性降低。结果表明，ＡＫＢＲ是反映胆原性脓毒症时肝细胞能量代谢状态有早期肝功能失常的灵敏指标。
The relationship of arterial ketone body ratio(AKBR)with the changes of energy metabolism of hepatocytes was studied in a rabbit model of biliary sepsis in which hepatic mitochondrial function and adenosine triphosphate(ATP)content were determined in the 12th, 24th and 48th h after the initiation of fbiliar sepsis,Respiratory impairment of hepatic mitochondria was demonstrated in the infected lobe in the 12th h after septic challenge by showing rapid decrease of state 3 respiratory rate,respiratory control ratio(RCR)and P/O ratio of the isolated mitochondria and a reduction of tissue ATP content.The decrease and the reduction became more severe when biliary sepsis advanced.AKBR was decreased continuously from the 12th h after sepsis when increased activity of RCR was shown in the non-infected liver lobes and RCR in the infected lobes was significantly lowered which was further lowered as sepsis went on.Our findings suggest that AKBR can serve as a sensitive indicator for the early hepatic metabolic derangement in biliary sepsis.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1995年第6期495-498,共4页
Journal of Third Military Medical University
关键词
呼吸功能
酮体比值
动脉血
脓毒症
胆原性
ketone body ratio
arterial blood
respiratory function mitochondria
biliary sepsis
rabbit
