摘要
目的:评价参麦注射液对早期子宫颈癌手术患者免疫功能的影响。方法:68例早期子宫颈癌手术患者被随机分成参麦组和对照组,每组各34例。参麦组于术后1d至术后7d,每天静滴参麦注射液50mL+5%葡萄糖300mL;对照组于术后1d至术后7d,每天单纯静滴5%葡萄糖300mL。全部病例于手术前(T1)、手术结束时(T2)及术后7d(T3)分别抽取外周静脉血,检测T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞数目。结果:手术结束时,两组CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞NK与术前相比均显著下降(P<0.05或P<0.01);术后第7d,两组各项指标恢复均有所恢复,但上升的幅度不同,参麦组上升的幅度大,基本达到术前水平,组间比较有显著差异(P<0.01)。结论:中药参麦注射液可以改善早期子宫颈癌手术患者的机体免疫功能抑制状态,促进患者免疫功能的恢复。
Objective：To investigate the effects of Shenmai injection on perioperation T-lymphocyte subsets and natural killer cells for patients received cervical cancer. Method： 68 patients with cervical cancer were randomly divided into two groups,34 patients were in each group. Shenmai group was received 50 mL Shenmai injection diluted with 300 mL 5% glucose 1 day before operation until 7 day after operation,and control group was received only 300 mL 5% glucose. Peripheral venous blood samples were taken before operation（ T1）,the end of operation（T2） and the seventh day after operation（T3） for determination of CD3 ＋ 、CD4 ＋ 、CD8 ＋ 、CD4 ＋ /CD8 ＋ and NK. Result： The CD3 ＋ 、CD4 ＋ 、CD8 ＋ 、CD4 ＋ /CD8 ＋ and NK were decreased in both groups at the end of operation （P 0. 05 or P 0. 01）. On the seventh postoperation day,the CD3 ＋ 、CD4 ＋ 、CD8 ＋ 、CD4 ＋ /CD8 ＋ and NK were returned to preoperational levels in both groups,but there was a significant change between the two groups（ P 0. 01）. Conclusion： Shenmai injection can improve the inhibition effects because of operation,and promote to recover the immunologic function for patients received cervical cancer.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第5期218-219,共2页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
参麦注射液
免疫
子宫颈癌
Shenmai Injection
Cellular Immunologic Function
Cervical Cancer
