摘要
目的探讨参麦注射液干预肿瘤化疗药物的毒性及免疫功能调节。方法将258例肿瘤患者随机分为治疗组与对照组。对照组给予常规化疗加对症治疗,治疗组在对照组治疗的基础上加用参麦注射液60ml加入到5%葡萄糖溶液500ml中静脉滴注,1次/d。两组患者治疗前、后均采血测定肝功能、血常规、免疫球蛋白及T细胞亚群。结果(1)治疗后两组患者ALT、AST和总胆红素间差异有显著性意义(P<0.01);(2)治疗后两组患者白细胞、血小板间差异有显著性意义(P<0.01);(3)治疗后两组患者IgG、IgA、IgM含量间差异有显著性意义(P<0.01);(4)治疗后两组患者CD4+、CD8+、CD4+/CD8+间差异有显著性意义(P<0.01)。结论参麦注射液具有干预化疗药物的毒性、改善肝功能、升高血象、增强患者免疫功能的作用。
Objective To investigate the resistance of Shenmai injection against toxicity of chemotherapy for tumor and its immune regulation function. Methods A total of 258 tumor patients were randomly divided as trial group and control group. The patients in control group received routine chemotherapy and symptomatic treatment; while those in trial group received intravenous Shenmai injection, 60 ml in 5% glucose solution 500 ml, once a day, based on the treatment for control group. All patients in the two groups were given tests of liver function, blood routine, immunoglobulin and T cell subsets before and after treatment. Results After treatment between the two groups, a significant difference in （1） alaninetransaminase （ALT） andaspartate aminotransferase （AST） wasfound （P〈0.01）; （2） leukocyte and blood phtelet counts （P 〈0.01）; （3） IgG, IgA, and IgM contents （ P 〈0.01） ; （4） CD4^＋ , CD8^＋ , and CD4^＋/CD8^＋ （ P 〈0.01）. Conclusion Shenmai injection is of the effects of checking the toxicity of chemical drugs, improving the liver functions, raising the blood picture, and strengthening the immunity.
出处
《中国全科医学》
CAS
CSCD
2006年第15期1237-1238,共2页
Chinese General Practice
关键词
参麦注射液
肿瘤
药物疗法
联合
干预性研究
Shenmai injection fluid
Tumour
Drug therapy, combination
Intervention studies
