Reg Ⅳ在溃疡性结肠炎中的表达及其对疾病活动度的预测价值被引量：2

Increased expression of Reg Ⅳ in ulcerative colitis provides a potential predictor of the disease activity

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摘要背景再生基因Ⅳ(Regenerating gene Ⅳ,RegⅣ)是钙依赖的植物血凝素超家族成员之一,主要位于胃肠道。目前缺乏RegⅣ与溃疡性结肠炎关系的研究报告。目的探讨RegⅣ与C反应蛋白、溃疡性结肠炎(ulcerative colitis,UC)活动度之间的关系。方法收集32例UC及10例健康查体者的肠黏膜及血清标本,通过免疫组化检测RegⅣ蛋白的表达水平。结果免疫组化染色提示Reg Ⅳ在UC患者肠黏膜中的表达水平较正常人明显升高(P<0.05)。The colitis activity index(CAI)与C反应蛋白呈中度正相关(r=0.529,P<0.01)。结论RegⅣ可作为预测UC活动程度的分子标志。 Background Regenerating gene Ⅳ（Reg Ⅳ）,a member of calcium dependent lectin gene super superfamily,is mainly expressed in gastrointestinal cells.Its role in inflammatory bowel disease is not clear now.Objective To study the relationship of RegIV and C reactive protein,CAI in ulcerative colitis.Methods Thirty-two patients with ulcerative colitis and 10 healthy controls were included in the study.Gene expression was investigated by immunohistochemistry.Results Immunohistochemical staining for Reg Ⅳ in the inflamed mucosa was significantly higher in ulcerative colitis than in controls（P〈0.05）.There was a positive correlation between CRP and CAI（the colitis activity index）expression in UC（r=0.529,P〈0.01）.Conclusion Reg Ⅳ level was a marker for predicting the disease activity in UC patients.

作者赖明广张亚历

机构地区广东省胃肠疾病重点实验室

出处《现代消化及介入诊疗》 2010年第2期71-73,共3页 Modern Interventional Diagnosis and Treatment in Gastroenterology

关键词再生基因家族蛋白Ⅳ 溃疡性结肠炎 C反应蛋白 Reg Ⅳ Ulcerative colitis CRP

分类号 R259.746.2 [医药卫生—中西医结合]

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