摘要
目的分析吉林省延边地区朝鲜族与汉族丙型肝炎病毒（HCV）基因型特征。方法采用荧光定量PCR方法和探针反向杂交技术对延边地区收治的62例朝鲜族和57例汉族慢性丙型肝炎患者进行HCV病毒载量检测和HCV基因型分析，比较HCV基因型在朝鲜族与汉族之间的分布差异，并分析HCV基因型与病毒载量、2型糖尿病和肝病严重程度之间的相关性。结果朝鲜族HCV基因型显示，1b型占45．16％（28／62）、2a型占38．71％（24／62）、未分型占16．13％（（10／62）；汉族HCV基因型显示，1b型占45．61％（26／57），2a型占40．35％（23／57），未分型占14．14％（8／57），朝、汉族之间各基因型分布差异无统计学意义（P〉0．05）。HCV各基因型之间HCV病毒载量差异和合并2型糖尿病分布差异之间无统计学意义（P〉0．05），而HCV1b型在中、重度慢性丙型肝炎患者与轻度慢性丙型肝炎患者中所占的比例差异具有统计学意义（P〈0．05）。结论①吉林省延边地区HCV基因型中以1b型最多，2a型次之，还有少数其他基因型；②HCV基因型在朝、汉民族之间分布无差异；③HCV基因型与HCV—RNA载量无关；④HCV基因型在合并糖尿病者与未合并糖尿病者之间分布无差异；⑤1b型HCV感染者病情相对较重。
Objective To investigate the characteristics of I-ICV genotypes of Han and Korean in Yanbian area of Jilin Province. Methods The HCV RNA load and genotypes of the 119 chronic hepatitis C patients in Yanbian area of Jilin Province were determined by real-time PCR and LiPA. The differences of the HCV genotypes in Han and Korean cases, in severity of the diseases, in HCV-RNA load, and in the relation with type 2 diabetes mellitus were analyzed. Results There was no significant difference in the distribution of each HCV genotype between Han and Korean patients （P 〉 0. 05 ） with chronic hepatitis C. The difference between HCV genotype and HCV-RNA load was not significant （P 〉 0.05 ）. With and without type 2 diabetes mellitus in these patients. The distribution of HCV genotype was also not significantly different （P 〉 0.05）. The type 1b of HCV genotype in the moderate to severe chronic hepatitis C patients accounted for 58.06%. It was different compared with mild chronic hepatitis C patients （P 〈 0. 05 ）. Conclusion （1）The type lb is the most popular HCV genotype in Yanbian area of Jilin Province, type 2a is the second and there are still a few other genotypes. （2）There is no significant difference in the distribution of HCV genotypes between Han and Korean cases. （3）The HCV genotypes has nothing to do with the load of HCV-RNA. （4）The distribution of HCV genotypes in chronic hepatitis C patients with and without diabetes mellitus is not significantly different. （5）Type lb of HCV infection is relatively severe.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2010年第2期104-106,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
肝炎病毒
基因型
人种群
Hepacivirus
Genotype
Ethnic groups
