摘要
目的探讨抑癌基因P16蛋白和VEGF蛋白在胃癌组织中的表达情况及与胃癌组织发生、发展的关系。方法用免疫组化Max VisionTM法对60例胃癌及癌旁组织检测P16蛋白和VEGF蛋白。结果 P16蛋白的总阳性率为63.33%(38/60,P<0.05),P16蛋白的阳性表达与胃癌组织的分化程度、癌组织的浸润程度、淋巴结有无转移及伴不伴有神经浸润有关。VEGF的总阳性率为61.67%(37/60,P<0.05),VEGF的阳性表达与胃癌组织的分化程度及浸润程度没有相关性,与淋巴结有无转移和伴不伴有神经浸润有关。结论 P16蛋白和VEGF蛋白与胃癌组织的发生、发展、预后关系密切,可作为胃癌患者术后预后、评估检测的指标。
Objective To explore the expression of P16 and VEGF proteins in the gastric cancer tissue and the relationship between their expression and the occurrence and development of gastric cancer. Methods The P16 and VEGF expression in 60 eases of gastric cancer and its adjacent tissue was detected by MaxVisionTM immunohistoehemieal method. Results The positive rate of P16 protein was 68.33（41/60, P〈 0.05 ）, and the P16 protein expression was correlated with gastric cancer tissue differentiation, cancer infiltration, lymph node metastasis and nerve infiltration. The positive rate of VEGF was 61.67%（37/60, P〈0.05 ）. The VEGF protein expression was not correlated with gastric cancer tissue differentiation and cancer infiltration, but was correlated with lymph node metastasis and nerve infiltration. Conclusion The expression of P16 and VEGF proteins is closely correlated with the occurrence,development and prognosis of gastric cancer,which can be used to evaluate the biological behavior and prognosis of gastric cancer.
出处
《中国现代医生》
2010年第11期88-89,96,共3页
China Modern Doctor
