摘要
目的检测结直肠癌P-gp的表达,探讨其临床意义。方法采用免疫组织化学MaxVisionTM二步法,检测结直肠癌标本78份,癌旁正常肠组织31份。结果P-gp表达阳性率为83.3%(65/78),与癌周正常组织比较差异有统计学意义(P<0.05),其表达与浸润深度有关,差异有统计学意义(P<0.05),与性别、年龄、临床分期、淋巴结转移无关,差异无统计学意义(P>0.05)。结论P-gp在结直肠癌的原发耐药上起着重要作用,检测P-gp的表达对大肠癌的化疗药物和方案选择具有参考意义。
Objective To study the expression and clinical significance of P-gp in colorectal carcinoma. Methods Immunohisto- chemistry was used to examine the P-gp expression in 78 cases of colorectal carcinoma and 31 cases of normal tissues. Results The positive expression of P-gp in colorectal carcinoma was 83.3% （65/78） ,higher than that in normal tissue（P〈0.05）. The expres- sion of P-gp was related to the degree of invasion（P〈0.05）,but not related to sex, age, clinical staging and nodal metastasis（P〉 0.05）. Conclusion P-gp play important roles in the primary multidrug resistance of colorectal carcinoma. Detecting the expression of P-gp in colorectal carcinoma has the referential significance with regard to the choice of drugs and plan in colorectal carcinoma chemotherapy.
出处
《重庆医学》
CAS
CSCD
北大核心
2009年第20期2580-2581,共2页
Chongqing medicine
关键词
结直肠癌
P-GP
免疫组织化学
colorectal carcinoma
p-glycoproteins
immunohistochemistry
