摘要
目的:检测非小细胞肺癌(NSCLC)患者血管内皮生长因子(VEGF)水平,以探讨二者之间的关系。方法:酶联免疫吸附法(ELISA)检测80例NSCLC患者和30例健康献血者VEGF含量。结果:NSCLC患者VEGF平均含量为(887.3±130.7)pg/mL,明显高于对照组(250.2±47.5)pg/mL(P<0.01),其水平与性别、年龄、组织学类型、分化程度、原发肿瘤大小无关,而与临床分期、淋巴结转移有关(P<0.01)。结论:VEGF可作为NSCLC早期诊断和预后评价的一个可靠参考指标。
Objective To detect the level of serum vascular endothelial growth factor（VEGF） in patients with non-small cell lung cancer（NSCLC）,and to explore its clinical significance.Methods The content of VEGF was measured by enzyme linked immunosorbent assay（ELISA） in 80 patients with NSCLC and 30 healthy controls.Results The average content of VEGF in patients with NSCLC was 887.3±130.7 pg/mL and significantly higer than that of control group（250.2±47.5 pg/mL）（P〈0.01）.The level of VEGF had no significant correlation with gender,age,histological type,degree of differentiation,size of tumor,but it was significantly correlated with clinical stage and lymphatic metastasis（P〈0.01）.Conclusion VEGF could be a reliable index for early diagnosis and prognostic evaluation of NSCLC.
出处
《郧阳医学院学报》
2009年第6期588-589,592,共3页
Journal of Yunyang Medical College
关键词
血管内皮生长因子
非小细胞肺癌
Vascular endothelial growth factor
Non-small cell lung cancer
