摘要
目的探讨survivin与宫颈鳞癌新辅助化疗(NACT)和放射治疗(RT)敏感性的相关性。方法新辅助化疗前后采用免疫组化(SABC法)法,检测32例宫颈鳞癌组织中survivin的表达。结果32例患者化疗前后survivin阳性表达率分别为68.8%(22/32)和56.3%(18/32),差异无统计学意义(P=0.302)。<45岁与≥45岁、Ⅰb～Ⅱa期与Ⅱb～Ⅲb期、高中分化癌与低分化癌、化疗前与化疗后survivin阳性表达率比较均无统计学意义(P>0.05)。化疗前survivin阳性表达患者NACT与NACT+RT总体疗效比较,差异均有统计学意义(P=0.030,0.009);survivin(+)组和(++)组NACT与NACT+RT的疗效比较,差异均有统计学意义(P≤0.05);survivin(-)组和(+++)组NACT与NACT+RT的疗效比较,差异均无统计学意义(P≥0.05)。结论宫颈鳞癌survivin表达与患者年龄、临床分期和肿瘤分化程度无明显相关性,NACT和NACT+RT对不同survivin表达程度患者的疗效有显著性差异,治疗前检测患者survivin表达水平可为预测化疗和放疗敏感性提供客观依据。
Objective To detect the correlation between expression of the survivin and the neoadjuvant chemotherapy （ NACT ） and radiosensitivity （ RT ） in cervical squamous cell carcinoma. Methods Using immunohistochemical methods （ SABC ） to detect the expression of survivin in pre-and post-neoadjuvant chemotherapy in 32 cases of cervical squamous cell carcinoma. Results The positive expression of survivin in pre- and post-ehemothrapy was 68.8% （22/32） and 56.3% （18/32） respectively in 32 cases,which showed no statistically significant difference （P = 0. 302）. There was also no statistically significant difference（P 〉 0.05 ）in age groups for 〈 45 years old and 1〉 45 years of age , Ⅰ b - Ⅱ a and Ⅱb - Ⅲb stages and high-middle pathological differentiated and low differentiated cacinoma. Compared to the total efficacy of positive expression of survivin between NACT and NACT ＋ RT in prechemotherapy,there was statistically significant difference （P = 0. 030,0. 009） ;While for survivin （ ＋ ） and （ ＋ ＋ ） , there also was statistically significant difference （ P ≤ 0.05 ） ; but for survivin （-） and （ ＋ ＋ ＋ ）, there was no statistically significant difference（ P≥0.05 ）. Conclusion There was no significant correlation for expression of survivin with different ages ,clinical stages ,and tumor differentiated degrees in cervical squamous cell carcinoma. There was significant correlation for expression of survivin with NACT and NACT ＋ RT. It showed negative correlation for expression of the survivin between the neoadjuvant chemotherapy（NACT） and radiosensitivity （RT）. To detect the survivin expression levels before treatment can provide objective basis for predicting sensitivity of chemotherapy and radiotherapy.
出处
《实用癌症杂志》
2010年第2期133-135,共3页
The Practical Journal of Cancer
基金
云南省教育厅科学研究基金项目(编号:07Y10362)
关键词
宫颈鳞癌
新辅助化疗
放射治疗
Cervical squamous cell carcinoma
Neoadjuvant chemotherapy
Radiotherapy
