期刊文献+

Survivin在乳腺癌中的表达及其与CD44v6、nm23表达的关系 被引量:5

暂未订购
导出
摘要 目的:探讨survivin、CD44v6、nm23在乳腺癌中的表达及其临床意义。方法:采用免疫组化技术检测51例乳腺癌组织和15例乳腺囊性增生组织中survivin、CD44v6和nm23的表达。结果:Survivin蛋白在乳腺囊性增生组织及乳腺癌组织中的阳性率分别为40.0%(6/15)、72.5%(37/51)(P<0.05)。Survivin蛋白表达与临床分期和淋巴结转移有关(P<0.05),与年龄、病理类型无关(P>0.05);Survivin与CD44v6表达正相关,而与nm23表达负相关。结论:Survivin、CD44v6、nm23可能在乳腺癌发生和发展中起重要作用,对乳腺癌的诊断、转移和预后的判断有参考价值。
出处 《实用医学杂志》 CAS 2006年第22期2631-2633,共3页 The Journal of Practical Medicine
  • 相关文献

参考文献3

二级参考文献17

  • 1Janica A.nm23蛋白在管腺型原位及浸润性乳腺癌中的表达[J].国外医学:遗传学分册,1994,17(3):146-147.
  • 2Ambrosini G, Adida C, Mtieri DC, et al. Induction of apoptosis and inhibition of cell proliferation by survivin gene targene. J Bilo Chem,1998, 273(18): 11177- 11182.
  • 3Ambrosini G, Adida C, Altiefi DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med, 1997, 3( ): 917- 921.
  • 4Bao R, Connolly DC, Murphy M, et al. Activation of cancer-specific gene expression by the survivin promoter. J Nail Cancer lnst, 2002, 94(7): 522-528.
  • 5Hay BA. Understanding lAP function and regulation: a view from Drosophila. Cell Death Differ. 2000, 7(11): 1045- 1056.
  • 6Suzuki A, Ito T, Kawano H, et al. Survivin intiates procaspase 3/p21 complex formatin as a result of interaction with CDK4 to resist Fas-mediated cell death. Oncozene, 2000, 19(10): 1346- 1353.
  • 7Yamamoto T, Tanigawa N. The role of survivin as a new target of diagnosis and treatment in human cancer. Med Electron Microse, 2001, 34(4) : 207 - 212.
  • 8Kim HS, Shiraki K, Park SH. Expression of survivin in CIN and invasire sqamous cell carcinoma of uterine cervix. Anticancer Res, 2002, 22(2A) : 805 - 808.
  • 9Chakravarti A, Noll E, Black PM, et al. Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Chin Oncol, 2002, 20(4): 1063- 1068.
  • 10Ambrosini G, Adida C, Altieri DC, et al. Induction of apoptosis and inhibition of cell proliferation by survivin gene targene. J Bilo Chem,1998, 273(18): 11177- 11182

共引文献17

同被引文献48

引证文献5

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部