摘要
目的探讨EGFR、P21蛋白和C-myc在肺癌中的表达及相互关系。方法用免疫组织化学方法(SABC法)观察EGFR、P21蛋白和C-myc在肺癌组织及邻近正常组织中表达。结果EGFR表达率87.01%,与组织类型明显有关(P<0.001),P21表达率为51.94%,腺癌中表达率为85.71%,与其它类型间有显著差异(P<0.01);C-myc阳性表达率为51.94%,腺癌和其它类型间有明显差异(P<0.05)。但未显示EGFR、P21蛋白和C-myc与分化程度的关系。结论EGFR、P21蛋白和C-myc在肺癌中均呈高表达,提示在肺癌发生中起重要作用。
Objective To investigate the expression of EGFR, P21 protein and C-myc in lung cancer and the relationship with clinicopathology of lung cancer. Methods The expressions of EGFR,P21 pretein and C- myc were observed by immunohistochemic （SABC） to observe in lung cancer and adjacent normal tissue. Results the positive rate of EGFR is 87.01%, it is related with tile histologic type （ P〈0.001 ） , the positive rate of P21 was 51.94%, and the expression rate in ad is 85.71% ,it has significant difference with other type （ P 〈0.05） . There were no significant between EGFR, P21 and C-myc and differentiate degree, but there has; significant between the expression of EGFR and clinic stage, the positive rate of I and II stages is higher than III and IV stages obviously （ P〈0.05） . Conclusion The expressions of EGFR, P21 and C-myc were significunth high in lung cancer , it indicated playing an important role in the lung cancer development.
