摘要
目的探讨转录信号传导子与激活子3(STAT3)、生存素(Survivin)及血管内皮生长因子(VEGF)在胃癌组织中的表达与临床病理特征之间的关系。方法采用免疫组织化学SABC法检测56例胃癌组织及其癌旁正常组织中STAT3和Survivin及VEGF的表达情况。结果STAT3与Survivin及VEGF在56例胃癌组织中的表达阳性率分别为75.0%、71.4%及76.8%,均明显高于三者在癌旁正常组织中的表达率(P<0.01),且在Ⅲ、Ⅳ期胃癌中的表达水平明显高于Ⅰ、Ⅱ期胃癌(P<0.01)。胃壁浆膜受侵、淋巴结有转移及低分化或未分化胃癌中,三者表达水平高于未侵及浆膜、淋巴结无转移及中、高分化的胃癌(P<0.05)。STAT3、Survivin及VEGF在胃癌组织中的表达水平两两之间均呈明显的正相关关系。结论STAT3、Survivin及VEGF的过度表达与胃癌的发生发展密切相关,STAT3的活化导致其下游靶基因Survivin及VEGF的表达明显升高,促使肿瘤迅速增长、浸润及转移。
Objective To investigate the expression of STAT3, Survivin and VEGF in gastric cancer and its correlation with the clinicopathological features. Methods SABC immunohisto-logical staining was used to detect the expression of STAT3, Survivin and VEGF in 56 cases with gastric cancer tissues and cancer around tissues. Results The expression rate of STAT3, Survivin and VEGF in 56 cases with gastric cancer tissues were 75.0 %, 71.4% and 76.8% respectively, much high- er than that of cancer around tissues （P 〈0. 01 ）. The expression rate in phase HI and IV of gastric cancer was much higher than that of phase I and 1I （P 〈0. 01 ）. The expression rates in serous membrane invasion of gastric wall, lymph nodes metastasis, poorly differentiated and undifferentiated gastric cancers were higher than that of no membrane invasion, no metastasis and mederately and well differentiated gastric cancers （P 〈 0. 05 ）. Positive correlation was found between the expressions of STAT3,Survivin and VEGF. Conclusion STA33, Survivin and VEGF play an important role in the pathogenesis of gastric cancer. Survivin and VEGF might be functioning on antiapoptosis through the regulation of STAT3 protein.
出处
《临床误诊误治》
2010年第3期214-216,共3页
Clinical Misdiagnosis & Mistherapy
