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STAT3信号转导通路与肿瘤耐药研究进展 被引量：2

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摘要 0引言转录信号传导子与激活子3（signal transducers and activators of transcription 3,STAT3）通路与细胞增殖、分化及凋亡密切相关,该通路持续激活可导致细胞异常增殖和恶性转化,因此被认为是一种癌基因。
作者 马向涛
机构地区 北京海淀医院外科
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2011年第4期474-475,484,共3页 Cancer Research on Prevention and Treatment
基金 北京市优秀人才培养基金资助项目(20061D0900500347)
关键词 STAT3 信号转导 肿瘤 耐药
分类号 R730.23 [医药卫生—肿瘤]
  • 相关文献

参考文献22

  • 1Bromberg JF, Wrzeszczynska MH, Devgan G, et al.Stat3 as an oncogene[J].Cell, 1999, 98(3):295-303.
  • 2马向涛.STATs信号转导通路与靶基因研究进展[J].肿瘤防治研究,2009,36(10):892-894. 被引量：3
  • 3Bewry NN, Nair RR, Emmons MF, et al.Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance[J].Mol Cancer Ther, 2008, 7(10):3169-3175.
  • 4Klampfer L.Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs[J].Curr Cancer Drug Targets, 2006, 6(2): 107-121.
  • 5Alvarez JV, Greulich H, Sellers WR, et al.Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer- associated mutations of the epidermal growth factor receptor[J].Cancer Res, 2006, 66(6): 3162-3168.
  • 6马向涛,王杉,杜如昱,叶颖江,崔志荣.Stat3反义寡核苷酸联合化疗调控结肠癌细胞增殖与凋亡的分子机制[J].中华实验外科杂志,2004,21(10):1212-1214. 被引量：25
  • 7Gu F, Ma Y, Zhang Z, et al.Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma[J].Oncol Rep, 2010, 23(3):671-676.
  • 8Rosen DG, Mercado-Uribe I, Yang G, et al.The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis [J].Cancer, 2006, 107(11):2730-2740.
  • 9Duan Z, Ames RY, Ryan M, et al.CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells[J].Cancer Chemother Pharmacol, 2009, 63(4):681-689.
  • 10Kim JH, Lee SC, Ro J, et al.Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines [J].Biochem Pharmacol, 2010, 79(3):373-380.

二级参考文献27

  • 1Klampfer L. Signal transducers and activators of transcription (STATs) : Novel targets of chemopreventive and chemothera peutic drugs[J]. Curr Cancer Drug Targets, 2006, 6(2):107 -121.
  • 2Ferrajoli A, Faderl S, Ravandi F, et al. The JAK-STAT pathway: a therapeutic target in hematological malignancies [J]. Curt Cancer Drug Targets, 2006, 6(8):671- 679.
  • 3Knudsen KE, Diehl JA, Haiman CA, el al. Cyclin D1:polymorphism, aberrant splicing and cancer risk[J]. Oncogene, 2006, 25(11 ): 1620-1628.
  • 4Leslie K, Lang C, Devgan G, et al. Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3[J]. Cancer Res, 2006, 66(5):2544 -2552.
  • 5Leeman RJ, Lui VW, Grandis JR. STAT3 as a therapeutic target in head and neck cancer[J]. Expert Opin Biol Ther, 2006, 6(3) :231-241.
  • 6Duan Z, Foster R, Bell DA, et al. Signal transducers and activators of transcription 3 pathway activation in drug resistant o varian cancer[J]. Clin Cancer Res, 2006, 12 (17) : 5055-5063.
  • 7Bromberg JF, Wrzeszczynska MH, Devgan G, et al. Stat3 as an oncogene[J]. Cell, 1999, 98(3):295-303.
  • 8Bott SR, Arya M, Kirby RS, et al. p21WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylation[J]. Prostate Cancer Prostatic Dis, 2005, 8 (4): 321-326.
  • 9Bellido T, O'Brien CA, Roberson PK, et al. Transcriptional activation of the p21 (WAF1, CIPI, SDI 1 ) gene by interleukin- 6 type cytokines. A prerequisite for their pro-differentiating and anti apoptotic effects on human osteoblastic cells[J]. J Biol Chem, 1998, 273(33):21137 -21144.
  • 10Bowman T, Broome MA, Sinibaldi D, et al. Stat3-mediated Myc expression is required for Src transformation and PDGF- induced mitogenesis[J]. Proc Natl Acad Sci USA, 2001, 98 (13) :7319-7324.

共引文献26

同被引文献13

引证文献2

二级引证文献9

肿瘤防治研究
2011年 第4期

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