摘要
目的：探讨遗传方式和遗传因素在胆石症发生中的地位与作用。方法：对１２８个胆石症先证家系和１５１个非胆石症对照家系进行胆石症家族史的分离比和遗传度研究，并相互比较。结果：胆石症患病率，病例组一级亲属（２５０％）高于对照组（１２３％），有显著差异（ｘ２＝４１６Ｐ＜００５）；遗传度，病例组一级亲属遗传度２１９２％，其中男性（３４６８％）高于女性（１２４０％）；胆石症的分离比０００２６８，低于０２５。结论：胆石症是一种多基因遗传病；遗传因素在胆石症发生中作用显著。
OBJECTIVE:To investigate the role and importance of mode of inheritance and heritability in cholelithiasis.METHOD:The segregation ratio and heritability were investigated among 128 cholelithiasis families(experimental group) and 151 non-cholelithiasis families(control group).RESULTS:Morbidity for the first generation in experimental group was 2 5%,significantly higher than control group(1 23%)( x 2=4 16, P <0 05).Inheritability for the first generation in experimental group was 21 92%,in which 34 6% was for man and 12 4% for woman.Segregation ratio between the two groups was 0 00268,lower than 0 25.CONCLUTION:cholelithiasis is a multi-gene hereditary disease.Geneti factors play a important role in incidence of cholelithiasis,especially for man.
出处
《九江医学》
1998年第3期151-154,共4页
Jiujiang Medical Journal
关键词
家族
遗传度
遗传因素
胆结石
cholelithiasis/family and heritage
segregation ratio
heritability
genetic factor
