摘要
通过遗传流行病学病例对照方法，对宜兴市２１４个家系（１０９个脑梗塞先证家系和１０５个对照家系）进行分离比、多基因遗传方式和遗传度的分析。结果表明：在病例和对照家系具有良好均衡可比性的前提下，脑梗塞的分离比为０．０５２９，显著低于０．２５，说明其不符合单基因遗传病的特征；多基因遗传方式的分析表明，其一级亲属的理论发病率为６．６７８％，与实际发病率８．６１１％相比，无统计学显著性差异，符合多基因遗传的特征；遗传度的估算显示；脑梗塞先证者的一级亲属中，遗传度为５３％，其中女性亲属的遗传度达５７％，显著高于男性亲属的３９．４％，说明在脑梗塞病因中，遗传因素起着一定的作用。
お genetic epidemiologic casecontrol study including 214 prdigrees(109 cases and 105 controls)was carried out to estimate the heritability(h2)and the segregation ratio of arteriosclerotic cerebral infarcation by using the methods of Falconer and LiMantelGart respectively in YiXing city,March 1997.The results showed that the nuclear family members were well comparatively.The segregation ratio was 00529,which was significantly less than 025.The theoretical incidence rate the first rank blood relatives in cases was 6678%,which was no significantly difference from actual rate(8611%),and P value was larger than 005,It means that the geneticmodel belonged to polygenetics.The heritability of the first rank blood relatives wasequal 53%(in male and female,they were respectively 394% and 57%).It suggested that the hereditary factor was important in the occurance of arteriosclerotic cerebral infarction.
出处
《中国公共卫生》
CAS
CSCD
北大核心
1998年第7期391-393,共3页
Chinese Journal of Public Health
基金
国际合作研究项目
关键词
脑梗塞
分离比
遗传度
病因
流行病学
Arteriosclerotic cerebral infarction Heritability Segregation ratio
