摘要
通过基于全人群的病例对照谱系调查，应用Ｌｉ－Ｍａｎｔｅｌ－Ｇａｒｔ法和Ｆａｌｃｏｎｅｒ法分别作分离比与遗传率估计。结果表明：（１）一级亲属大肠癌曾患率（‰）分别为：对照组２．７，大肠癌组７．４，结肠癌组９．４，左半结肠癌组９．６，右半结肠癌组６．７，直肠癌组４．９；（２）各先证者组别分离比均显著低于０．２５（在０．０１６～０．０２２之间）；（３）各组一级亲属遗传率明显高于二级亲属；不同先证者一级亲属组间遗传率比较，左半结肠癌组为２８．５％，右半结肠癌组２０．０％，直肠癌组１２．９％。
A population-based case-control family study including 2 779 pedigrees(1 328 incident cases and 1451 population controls)was carried out to estimate the segregation ratios and the heritability(h2)of large bowel cancer(LBC)by using the method of Li-Mantel-Gart and Falconer,respectively,and,further to clarify the genetic feature of different sites of LBC.The results showed that the cumulative incidence rates(CIR)of the frist degree relatives(FDR)of index cases were markedly higher than the rates of the second degree relatives(SDR).The CIR of FDR were 2.7 per 1 000 in the group of LBC,9.4 in colon cancer,9.6 in left colon cancer,6.7 in right colon cancer and 4.9 in rectal cancer The segregation ratios were significantly less than 0.25(0.016-0.022)in every proband groups. The heritability(h2)in FDR of index patients was remarkably higher than that in SDR,and a correlation between heritability and subsite of LBC showed that the heritability was 28.5%in the FDR of probands with left colon cancer,20.0%in the right colon cancer group and 12.9%in the rectal cancer group.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1994年第1期9-11,共3页
Chinese Journal of Medical Genetics
基金
上海市科学技术发展基金
"八五"攻关项目
关键词
大肠肿瘤
流行病学
分离比
遗传率
Large bowel neoplasm
Genetic epidemiology
Segregation ratio
Heritability
