摘要
目的 探索胆石病家族聚集性及遗传方式。方法 采用遗传流行病学病例对照研究方法 ,对 317个家系 ( 138个胆石病先证家系和 179个对照家系 )进行研究。结果 病例组一级亲属总的胆石病患病率为 2 .60 % ,显著高于对照组的 1.2 9% ( χ2 =4.78,P =0 .0 2 88) ;分离比为显著低于 0 .2 5 ,不符合单基因遗传疾病的特征 ;遗传度估算显示 ,该病一级亲属中 ,遗传度为2 1.80 % ,其中男性亲属的遗传度为 36.34% ,显著高于女性亲属的 14 .15 %。结论 在胆石病的病因中 ,遗传因素起一定作用 ,尤其对男性作用更为明显。
Objective To explore the genetic model of gallstone disease (GD). Methods A case- control study including 317 pedigrees (138 cases and 179 controls) was conducted. Results The prevelence of the first-degree relatives in cases was 2.60 %, significantly higher than that noticed in controls ( 1.29 %). Segregation analysis showed that GD did not possess the characteristics of monogenic model. Meanwhile the results showed that the heritability of the first-degree relatives was 21.80 %,with male 36.34 % which was significantly higher than the females ( 14.15 %). Conclusion This study indicated that the genetic factors played an important role in the occurrence of GD, especially in males.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
1999年第5期293-295,共3页
Chinese Journal of Epidemiology
