摘要
近年来血卟啉衍生物（ＨｅｍａｔｏｐｏｒｐｈｙｒｉｎＤｅｒｉｖａｔｉｖｅ，ＨＰＤ）在基础医学与临床上对癌细胞的较强杀伤作用研究已取得了不少进展，但它不易从血清中制备，在肝脏有太多积聚，对体表皮肤有光毒反应等缺点，同时它的主吸收峰在紫光波段（４０５ｎｍ）...
Sulfonated aluminium phthalocyanine (ALSPc) was synthesizedvia sulfonating aluminum phthalocyanine.The product is a mixture with different sulfonic groups on the macrocycle of phthalocynine molecule,and was used as photosensitizer in this work. A dye laser driven by an argon laser was employed to provide monocolor light,which was used as radiation source in the photosensitizing investigation. The number of living cells survived from radiation was detected by MTT method.The photosensitization effects of both ALSPc and HPD (hematoporphyrin deriviatives)were compared with each other.When the concentration of ALSPc was 10.76 μg/mL,and the energy density of light used was 5 J/cm 2,fifty percent of gastric cancer cell were killed;however,the concentration of HPD at 24.83 μg/mL was reguired for getting the same result.It was found that the absorbance of ALSPc at 677 nm was 19 times than that of HPD at 630 nm,maybe implying that ealue ALSPc is a more effective photosensitizer in photodynamic treatment (PDT) of cancer.
出处
《厦门大学学报（自然科学版）》
CAS
CSCD
北大核心
1998年第6期936-940,共5页
Journal of Xiamen University：Natural Science
