摘要
目的探讨膀胱癌药敏试验指导膀胱灌注的远期疗效。方法将80例非肌层浸润性膀胱癌患者随机分为药敏组和对照组,每组40例,2组均行经尿道膀胱肿瘤电切术。术后药敏组根据药敏试验结果选择化疗药物进行膀胱灌注,对照组根据经验随机应用化疗药物灌注,2组均为单药灌注。随访24～72个月。结果2组所有患者均获得随访。药敏组复发7例,复发率17.5%;对照组复发12例,复发率30.0%,2组比较差异有统计学意义(P<0.05)。结论肿瘤药敏试验指导膀胱癌患者膀胱灌注化疗药物的选择,能显著地降低膀胱癌的复发率,具有良好的远期疗效。
Objective To evaluate the long term effect of drug sensitivity test for intravesical instillation for bladder cancer. Methods 80 patients with non-invasive bladder cancer after TURBt were divided into two groups randomly ：40 cases of drug sensitivity group received intravesical instillation according the results of drug sensitivity test ;40 cases of control group were given intravesical instillation basing on the experience of doctors. All the patients were followed up for 24 to 72 months. Results All of the two groups were followed up, recurrence rate was 17.5% （7/40）in drug sensitivity group and 30% （12/40）in control group. The difference was significant （P 〈 0. 05） . Conclusion Drug sensitivity test for the selection of drugs for intravesical instiUation can reduce the recurrence rate of bladder cancer significantly and limprove the long-term efficiency of treatment of bladder cancer.
出处
《河北医药》
CAS
2010年第1期21-22,共2页
Hebei Medical Journal
基金
河北省普通高校强势特色学科基金资助项目
关键词
膀胱肿瘤
药物敏感试验
腔内灌注
bladder tumor
drug sensitivity test
intravesical instillation
