摘要
目的 研究大肠癌体外化疗药物敏感性与临床疗效的关系,为临床肿瘤化疗个体化提供依据。方法 用改进的MTT法测定53例结、直肠癌组织的化疗药物敏感性,并依药敏结果选择化疗方案,观察临床近期疗效和远期生存率。结果 53例结、直肠癌组织对8种化疗药物的敏感顺序为5-氟脲嘧啶(5-Fu)、顺铂(DDP)、丝裂霉素(MMC)、阿糖胞苷(ARA-C)、长春新碱(VCR)、氨甲喋呤(MTX)、阿霉素(ADM)、卡氮芥(BCNU),除DDP、5-Fu、MMC的敏感率高于文献报道的单药有效率外,其余与文献报道有效的单药基本一致。体外敏感性与临床近期疗效的总符合率为91.7％(11/12),药敏试验组和按经验给药组的3年生存率无明显区别,但药敏试验组5年生存率明显高于按经验给药组(P<0.05)。结论 MTT法测定化疗药物敏感性可帮助临床医师制定合理的化疗方案,按药敏试验结果指导化疗可能会有助于提高大肠癌患者的远期存活率。
Objective To provide the guidance for individual chemotherapy in patients with colorectal cancer, the chemosensitivity was determined. Methods Chemosensitivity in vitro of 53 cases with colorectal cancer was determined by modified MTT method and chemotherapeutic regimens were selected according to the results of chemosensitivity. Patients' therapeutical benefit of the chemosensitivity regimen guided by chemosensitivity test and convenient regimen was investigated. Results The chemosensitivity order for 53 cases with colorectal cancer was fluorouracil, cisplatin, mitomycin, cytarbine, vincristin, methotrexate, doxorubicin, bis chloroethyl nitrosourea and their sensitivity rates except ones of cisplatin, fluorouracil and mitomycin were consistent with those for effective drugs on colorectal cancer proved by clinical practice. The total coincidence rate of chemosensitivity in vitro and therapeutic effectiveness for short term was 91.7% (11/12).The survival rate of three years had no significant difference between experimental group and control group, but the survival rate of five years in the experimental group was higher than that in the control group. Conclusion Chemotherapy under the guidance of chemosensitivity in vitro may improve the long term survival rate of colorectal cancer.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2003年第5期341-344,共4页
The Chinese Journal of Clinical Pharmacology
