摘要
目的:了解我院药品不良反应(ADR)发生情况及相关因素,为合理用药提供参考。方法:对我院2007年11月～2008年10月收集的246例ADR报告进行统计、分析。结果:246例ADR报告共涉及120种药品,静脉滴注是引起ADR的主要给药途径(64.63%);抗微生物药发生率最高(42.28%),其次是中枢神经系统药(13.01%)、循环系统药(10.57%)、中药制剂(7.32%);中药注射剂引起的ADR占所有中药制剂的50.00%;临床表现主要为皮肤及其附件损害(51.63%);严重的ADR有11例(4.47%),新的ADR有1例(0.41%)。结论:ADR的发生与多种因素有关,临床应加强ADR监测工作,以减少或避免ADR的发生。
OBJECTIVE： To study the situation and the related factors of ADR occurred in our hospital and to provide references for rational use of drug. METHODS： A total of 246 ADR case reports collected in our hospital from Nov. 2007 to Oct. 2008 were analyzed statistically. RESULTS： Of the 246 ADR cases, 120 kinds of drugs were involved. 64.63% of ADR were induced by intravenous drip infusion; 42.28% were antimicrobial, 13.01% were drugs for central nervous system, 10.57 % were for circulation system, 7.32% were TCM preparation; ADR-inducing TCM injection accounted for 50.00% in TCM preparations. The main clinical manifestation represented as lesion of skin and its appendants （51.63%）. 11 severe cases accounted for 4.47% and 1 new cases only 0.41%. CONCLUSION： ADR may be caused by many factors. The most attention should be paid to monitoring ADR in the clinic so as reduce or avoid occurrence of ADR.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第6期533-535,共3页
China Pharmacy
