摘要
内皮细胞形成了大分子物质和循环细胞从血液到组织的最主要屏障，内皮细胞的通透性主要是通过内皮细胞间连接进行调控的，本文从内皮细胞间连接的几种方式，信号的转导，连接变化的调控，血管中液体的流动及中性粒细胞渗出对内皮细胞间连接的影响进行阐述，讨论了目前内皮细胞间连接的研究进展，提出内皮细胞间连接和骨架结构对血管通透性的调控，中性粒细胞的渗出和血管内皮细胞间连接的重建都具有非常重要的作用，其中内皮细胞间粘附连接是最重要的一种连接方式。
The endothelium forms the main barrier to the passage of marcromolecules and circulating cells from blood to tissues. Endothelial permeability is in large part regulated by intercellular junction. The article here dicusses the development of endothelial cell to cell junction. The types of endothelial junctions, transduction , regulation of changes of endothelial cell to cell junction, the effects of the flow in vasculature and the leukocytic extravasation have been discussed. It was emphasized that the changes of endothelial junctions and skeleton were important in regulating endothelial permeability, leukocyte extravasation and reorganization of vascular endothelial cell to cell junction.
出处
《生理科学进展》
CAS
CSCD
北大核心
1998年第4期314-318,共5页
Progress in Physiological Sciences
