摘要
血管内皮细胞构成了大分子物质和循环细胞从血液到组织的重要屏障,稳定了血液的胶体渗透压,调节血管张力,并能快速改变细胞间连接方式,允许血浆和循环的白细胞通过,维持正常的生理功能。血管屏障通透性增加是脓毒症,急性肺损伤/急性呼吸窘迫综合征,重症肺炎,创伤,烧伤,缺血/再灌注损伤,糖尿病性视网膜病变,糖尿病肾病,热损伤等疾病发生、发展中的一个重要病理特征,其通透性改变直接与细胞间连接功能状态密不可分。该文就细胞间连接的主要组成部分,紧密连接的结构、功能、信号通路及调节因素作一综述,旨在对紧密连接有更一步的认识和了解。
Vascular endothelial cells constitute an important barrier of macromolecules and circulating cells from the blood into the tissue, stabilize the colloid osmotic pressure of the blood, regulate vascular ten- sion, and can quickly change the connections between the cells, allowing the plasma and circulating leukocyte to go through to maintain normal physiological function. Endothelial barrier dysfunction is an important con- tributor to the pathogenesis of sepsis, ALI/ARDS, severe pneumonia, trauma, bums, ischemia-reperfusion injury,diabetic retinopathy, diabetic nephropathy, and thermal damage. The permeability change is directly affected by the function of the connections between cells. Here is to make a review on the connections between the cells from the perspectives of function, signaling pathways, adjustment factors, with the aim of further understanding of the tight junction.
出处
《医学综述》
2013年第11期1944-1947,共4页
Medical Recapitulate
关键词
紧密连接
血管内皮
通透性
Tight junctions
Vascular endothelium
Permeability
