摘要
在大鼠止血带休克(ToS)模型上,观察到口服牛磺酸增加动物组织牛磺酸含量,可有效地避免ToS大鼠血压的进行性降低,减少胞浆酶和溶酶体酶的漏出,抑制组织脂质过氧化的发生,阻止骨骼肌线粒体钙积聚和延长动物存活时间。而应用β-丙氨酸减少动物组织牛磺酸含量使休克加重,缩短动物存活时间。结果提示,牛磺酸可能参与机体在缺血—再灌注损伤时的防御反应。
It was found on the rat tourniquet shock model that oral administrationof taurine increased the taurine tissue level in rat, which prevented the shocked animalsfrom a progressive hypotension, attenuated the enzyme leakage from cytoplasma and lyso-somes, inhibited the formation of tissue lipid peroxide, lowered the mitochondria calciumaccumulation of skeletal muscle, and prolonged the survival time of the shocked rats sig-nificantly. When the tissue taurine content in rats was decreased by pre-administration ofβ-alanine, the tourniquet shock was markedly deteriorized and the survival time of theshocked rats was shortened significantly. These results suggest that taurine could have par-ticipated in the body defensive mechanism against the ischemia-reperfusion injury.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1993年第2期208-210,共3页
Chinese Journal of Pathophysiology
关键词
氨基酸
丙氨酸
休克
局部缺血
Amino acids
Alanine
Shock
Ischemia-reperfusion injury
