摘要
目的观察应用降纤酶治疗颈动脉易损斑块的临床疗效。方法颈动脉易损斑块形成患者分为两组:治疗组和对照组。治疗组予生理盐水100mL+降纤酶10IU静脉滴注(静滴),每周2次,连续4周,同时洛伐他汀40mg,口服,1次/晚,连续4周。对照组予洛伐他汀40mg,口服,1次/晚,阿斯匹林肠溶片100mg,口服,1次/d,连续4周。两组治疗前及治疗后2周、4周检测易损斑块面积及血TC、LDL、HDL、TG。结果治疗组较对照组易损斑块消退或明显缩小。结论应用降纤酶稳定或消除颈动脉易损斑块疗效可靠、安全。
[Objective] To observe the clinical effect of defibrase in treating carotid vulnerable atheromatous plaque. [Methods] 126 patients with carotid vulnerable atheromatous plaque were divided into two groups： the observed group and the controlled group. The observed group （66 cases） was given defibrase 10 U, 2 times a week for four weeks. Meanwhile all patients were given tablet Lovastatin 40 mg, once every night for 4 weeks. The controlled group was given Lovastatin tablet 40 rag, once every night for 4 weeks. Aspirin 100 mg once day for 4 weeks. Observing the plaque area, the level of blood TC, LDL, HDL, TG pre-treatment and post-treatment （about 2 week, 4 week after treatment）. [ Results ] After treatment, the plaque area reduced, the blood lipid decreased, there were significant differences between before and after treatment （P〈0.05）. [ Conclusion ] The effective was reliable and safety in using defibrase in stabilizing the vulnerable atheromatous plaque.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第18期2795-2798,共4页
China Journal of Modern Medicine
关键词
易损斑块
降纤酶
洛伐他汀
动脉疾病
vulnerable atheromatous plaque
defibrase
Lovastatin
artery disease
