摘要
目的探讨芪莲汤颗粒剂对糖尿病肾病(diabetic nephropathy,DN)大鼠体内炎性因子C-反应蛋白(creac-tion protein,CRP)、白细胞介素6(interleukin-6,IL-6)及尿液N-乙酰-β-d-氨基葡萄糖苷酶(N-acetyl-β-D-glucosamini-dase,NAG)含量的影响,研究芪莲汤颗粒剂的作用机制。方法采用高糖高脂饲料联合链脲佐菌素腹腔注射的方法建立DN动物模型,设正常对照组、模型对照组、芪莲汤颗粒剂高剂量组及芪莲汤颗粒剂低剂量组。药物干预模型动物4个月后取血清测定CRP、IL-6含量;取尿液测定其中NAG的含量。结果芪莲汤干预后血清中CRP、IL-6含量降低;尿液中NAG排出减少。结论芪莲汤颗粒剂可以降低DN大鼠体内CRP、IL-6含量,对大鼠体内的炎症状态有纠正作用;能降低大鼠尿液中的NAG酶含量,对大鼠的肾功能有保护作用。
Objective To explore the effect of QiLian soup-granula on expressions of interleukin 6 （IL-6）, C-reac rive protein （CRP） and N-acetyl-β-d-glucosaminidase （NAG） in rats with diabetic nephropathy （DN） and to reseach its mechanism. Methods Rats were treated with high calorie feeds and streptozotocin （STZ） to establish the DN model. DN rats were administrated with QiLian soup-granula for four months. And then the level of IL-6, CRP in serum and NAG in urine were tested. Results Four months after the interference by QiI.ian soup-granula, the level of IL-6, CRP in serum and NAG in urine decreased for the model rats. Conclusion QiLian SOUl〉granula can decrease the level of IL 6 and CRP in serum and NAG in urine. It can correct the inflammation state and protect lhe renal functinn in DN-rats
出处
《华南国防医学杂志》
CAS
2009年第6期25-27,共3页
Military Medical Journal of South China
