摘要
目的:探讨百令胶囊治疗早期糖尿病肾病(diabetic nephropathy,DN)的作用机制。方法:将60例早期DN患者随机分为百令胶囊组和福辛普利组各30例,治疗3个月。在治疗前后用流式细胞仪检测T细胞亚群,用放射免疫法检测白介素-2(interleukin-2,IL-2)水平。结果:治疗前福辛普利组和百令胶囊组患者血清IL-2水平、CD4+细胞百分率和CD4+/CD8+比值显著低于正常对照组(P<0.01),CD8+细胞百分率显著高于正常对照组(P<0.01)。与治疗前比较,福辛普利组和百令胶囊组患者血清IL-2水平、CD4+细胞百分率显著升高(P<0.01)。百令胶囊组患者血清IL-2水平、CD4+细胞百分率显著高于福辛普利组(P<0.01)。结论:调节T淋巴细胞亚群和IL-2水平可能是百令胶囊治疗早期DN的重要机制之一。
To explore the possible mechanism of Bailing Capsule in treating early diabetic nephropathy （DN）. Methods： Sixty patients with early DN were averagely randomized into Bailing Capsule group and Fosinopril group. The treatment course was 3 months. T lymphocyte subpopulation was detected using flow cytometry, and the serum level of interleukin-2 （IL-2） was assayed using radioimmunoassay before and after treatment. Results： Before treatment, the percentage of CD4^＋ cells, the ratio of CD4^＋/CD8^＋ and the level of IL-2 in Bailing Capsule group and Fosinopril group were significantly lower than those in normal control group （P〈0.01）, while the percentage of CD8^＋ cells was significantly higher than those in normal control group （P〈0.01）. The serum level of IL-2 and the percentage of CD4^＋ cells in Bailing Capsule and Fosinopril groups were significantly increased after treatment compared with those before treatment （P〈0.01）. Furthermore, the IL-2 level and the percentage of CD4^＋ in Bailing Capsule group were significantly higher than those in Fosinopril group （P〈0.01）. Conclusion： The mechanism of Bailing Capsule in treating early DN might correlate with its regulating the T lymphocyte subpopulation and the level of IL-2.
出处
《安徽中医学院学报》
CAS
2009年第6期16-18,共3页
Journal of Anhui Traditional Chinese Medical College
关键词
糖尿病肾病
T淋巴细胞亚群
白介素-2
百令胶囊
Diabetic nephropathy
T lymphocyte subpopulation
Interleukin-2
Bailing Capsule
