摘要
本文通过建立四动脉夹闭所致大鼠急性全脑缺血—再灌注模型，以脑含水量、局部脑组织血流量（ｒＣＢＦ）、血清和脑组织中一氧化氮（ＮＯ）含量为观察指标，初步研究了脑络通过对缺血性脑损伤保护作用的机理。结果表明：脑络通对缺血性脑损伤具有明显的保护作用，且其作用主要是通过激活Ｌ－ａｒｇ——Ｎｏ通路来实现的。
To study the protective effect of Naoluotong(NLT) on cerebral ischemia,the acute whole cerebroischemia reperfusion rat model established by 4 occlusion vessels(4 ov) was used.The content of the cerebral tissue water,the regional cerebral blood flow(rCBF) and the nitric oxide(NO) content of brain and serum were observed.The results suggested that NLT can protect brain from ischemic damage by activating L arg NO pathway.
出处
《中国中医基础医学杂志》
CAS
CSCD
1998年第7期36-38,共3页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
脑络通
一氧化氮
L-NNA
缺血性脑损伤
脑水肿
Naoluotong(NLT),nitric oxide(NO),N G nitrio L arginine,cerebroischemia damage,regional cerebral blood flow(rCBF),brain edema
