摘要
目的:探讨子痫前期患者血清肝细胞生长因子(HGF)和抑制素A(Inhibin A)水平的变化及临床意义。方法:分别采用酶联免疫法和放射免疫分析35例子痫前期孕妇(子痫前期组)和35例正常妊娠孕妇(对照组)血清HGF和Inhibin A水平。结果:结果显示,子痫前期患者与对照组孕妇新生儿出生体重、胎盘重量差异无统计学意义(P均>0.05)。子痫前期患者不同病情血清HGF和Inhibin A测定结果表明,无论轻度子痫前期组和重度子痫前期组患者血清HGF含量均非常显著地低于对照组(P均<0.01);但轻度子痫前期组和重度子痫前期组之间HGF水平无显著差异(P>0.05)。Inhibin A水平则轻、重两组均非常显著地高于对照组(P均<0.01);且轻、重两组之间比较重度组非常显著地高于轻度组(P<0.01)。相关分析结果显示,血清HGF和Inhibin A水平两组指标数值之间均无显著相关性(r=0.189,P>0.05)。子痫前期患者胎盘重量与血清HGF和Inhibin A水平之间也无显著的相关性(r=-0.037、0.235,均P>0.05)。结论:患者血清HGF和In-hibin A水平的变化参与了子痫前期的发病机制,其测定对于子痫前期的病情评估有帮助。
Objective To study the clinical significance of changes of serum hepatocyte growth factor（HGF） and inhibin A levels in patients with pre-eclampsia.Methods Serum levels of HGF（with ELISA） and inhibin A（with RIA） were determined in ① 17 patients with mild pre-eclampsia ② 18 patients with severe pre-eclampsia and ③ 35 controls.Results As a whole,the birth weight of neonates and placenta weight in patients with pre-eclampsia were not significantly different from those in control normal pregnant women（P〉0.05）.The serum levels of HGF in patients with either mild or severe pre-eclampsia were very significantly lower than those in controls（P〈0.01） with no significantly differences between the levels in the two groups of patients（P〉0.05）.For inhibin A,the serum levels in both groups of patients were very significantly higher than those in controls（P〈0.01） with also significant differences between the levels of the two groups（P〈0.01）.Levels of HGF and inhibin A were not mutually correlated（r=0.189,P〉0.05）.Again,the placenta weight in patients with pre-eclampsia was not correlated with the serum HGF or inhibin A levels（r=-0.032,r=0.235,both P〉0.05）.Conclusion Determination of serum HGF and inhibin A levels was helpful for assessment of the disease process in patients with pre-eclampsia.
出处
《放射免疫学杂志》
CAS
2009年第6期564-567,共4页
Journal of Radioimmanology
