摘要
目的探讨血清肝细胞生长因子(HGF)和CA125水平对子宫内膜异位症(EMs)的诊断价值。方法采用酶联免疫吸附法(ELISA)和化学发光免疫分析法检测45例EMs患者血清HGF和CA125水平,并将其和正常组、对照组作比较。结果 EMs患者血清HGF和CA125水平及阳性率均明显高于正常组、对照组(P<0.05),HGF和CA125联合检测如以两项之一高于正常参考值为阳性判断标准,EMs组阳性率为84%,高于单一检测的71%和60%,而Ⅲ～Ⅳ期阳性率达100%。联合检测如以两项均高于正常参考值为阳性判断标准,敏感性虽下降为43%,但特异性为99%,阳性预测值高达100%。结论血清HGF对EMs的诊断有一定的价值,与CA125联合检测有助于提高EMs的诊断准确性。
Objective To investigate the value of hepatocyt growth factor（HGF） in the pathogenesis of endometriosis（EMs） and its clinical potential value. Methods Enzyme linked immunosorbent assay（ELISA） method was involved in determining the ex- pression of HGF and CA125 in serum in the endometriosis group（EMs）（n~ 45） and the normal control group（n~ 45）. Results The expressions of HGF and CA125 in the EMs group were obviously higher than those in the control group with statistical differ- ence（P^0. 05）. In combined detection of HGF and CA125, the positive rate was 84 % in the endometriosis group, higher than 71% and 60% in the single index test respectively,meanwhile which would be up to 100% in stage III-IV. These indicated the combina- tion detection could improve the positive rate in endometriosis, the sensitivity dropped to 43% ,whereas the specificity was up to 99 %, and the positive predictive value climbed up to 100 %. Conclusion The expression of HGF might be involved in the pathogen- esis of endometriosis, and the combination detection of serum HGF and CA125 is conducive to increase the diagnosis accuracy of en- dometriosis.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第16期1589-1590,1592,共3页
Chongqing medicine
