摘要
目的 探讨肝细胞生长因子 (HGF)及循环内皮细胞水平变化与妊娠高血压综合征 (妊高征 )患者血管内皮细胞 (VEC)损伤的关系。方法 选择 2 0例妊高征患者 (其中轻度 6例 ,中、重度14例 )为妊高征组 ;2 0例正常妊娠妇女为对照组。两组孕妇的年龄、孕龄、产次比较 ,差异无显著性(P >0 0 5 )。采用流式细胞仪检测两组孕妇外周血中循环内皮细胞 (CEC)水平 (细胞个数 ) ;采用酶联免疫吸附法检测两组孕妇血清HGF水平。结果 妊高征组CEC为 (10 936 0± 2 4 0 70 )个 /L ,HGF为 (1395± 5 12 )ng/L ;对照组CEC为(2 180 0± 4 4 2 0 )个 /L ,HGF为 (15 6 5± 399)ng/L。两组比较 ,差异有极显著性 (P <0 0 1)。两组的CEC与HGF之间 ,呈明显的负相关 ,相关系数 (r) =- 0 6 0 8(P <0 0 1)。
Objective To investigate the relationship between hepatocyte growth factor (HGF) and vascular endothelial cells (VEC) in pregnancy induced hypertension (PIH) Methods Twenty women with PIH (6 mild, and 14 moderate or severe PIH ) and 20 women with normal pregnancy were recruited as study group and control group, respectively The two groups were matched in maternal age, parity and gestational age Flow cytometer was used for counting the number of peripheral blood circulating endothelial cells (CEC), while enzyme linked immunoadsordent assay (ELISA) was used to measure the concentration of serum HGF Results In the study group, the concentration of HGF was (1395±512) ng/L, and the number of CEC was (109 360±24 070) /L In the control group, the concentration of HGF was (1565 ±399) ng/L, and the number of CEC was (21 800±4420)/L The differences both in the concentration of HGF and the number of CEC between the two groups were statistically significant ( P <0 01) Negative correlation between CEC and HGF was found both in study group and control group ( r =-0 608, P <0 01) Conclusion Decreased HGF may be related to VEC damage in the development of PIH
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2004年第1期18-20,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠高血压综合征
循环内皮细胞
肝细胞生长因子
血管内皮
Endothelium, vascular
Hepatocyte growth factor
Pregnancy complications, cardiovascular
Hypertension
