摘要
目的:优化槲皮素铜配位化合物的合成条件。方法:采用正交试验对槲皮素与乙酸铜络合反应的工艺参数进行优化。结果:反应温度对槲皮素铜配合物的产率具有显著影响,通过方差分析得到优化的络合反应条件为:槲皮素与乙酸铜摩尔质量配比为1∶1,在60℃络合反应30min,产率为82.10%。结论:该工艺稳定可行,槲皮素铜配合物产率较高。
Objective ：To optimize the synthesis of quercetin Cu complex. Methods ：The synthesis process was employed with ortbogonal design to optimize the complexing conditions for making quercetin Cu complex. Results：A mathematical model was then developed to show the significant effect of temperature on the yield of quercetin Cu complex. The analysis was used to estimate that a maximal yield of quercetin Cu complex could be obtained when the molar ratio of quercetin to cupric acetate was 1 ： 1 ,temperature was 60℃ and time was 30min. The yield of quercetin - Cu complex was 82.10%. Conclusion：The extraction process is stable and feasible.
出处
《中华中医药学刊》
CAS
2009年第12期2585-2586,共2页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省科技厅新苗人才计划项目(2007R40G2120040)
关键词
合成
槲皮素
槲皮素铜配合物
正交试验
synthesis
quercetin
quercetin–Cu complex
orthogonal design
