摘要
目的：探讨DNA含量与AgNOR对甲状腺良恶性滤泡性肿瘤的鉴别诊断价值。方法：应用流式细胞术和胶体银染技术对9例正常甲状腺组织和36例滤泡性肿瘤（22例腺瘤和14例腺癌）进行DNA含量分析和AgNOR计数。结果：14例滤泡性癌中，11例为DNA异倍体，而22例滤泡性腺癌仅1例为DNA异倍体，且伴有不典型增生。AgNOR由正常甲状腺组织、滤泡性腺癌至滤泡性癌逐渐增加，相互之间有显著性差异（P＜0．05）；但各组间AgNOR计数有重叠，且DNA含量与AgNOR无明显相关性。结论：尽管AgNOR染色方法简便。经济，但在区别良恶性滤泡性肿瘤方面，DNA含量异常更具意义。
To assess the diagnostic valoc of the DNA content and AgNOR in the distinchon of thethyorid follicular carcinoma from adenoma .Methods:DNA content and AgNOR coun in 9 normal thyroid tissue and 36 thyroid neoplasms (22 follicular adenomas and 14 follicular carcinomas ) were analysed byflow cytometry and silver colloid techmque ,Results : 11 of 14 carcinomas were DNA aneuploidy ,while inthe 22 cases of adenomas only 1 was DM aneuploidy with dysplasia. AgNOR increased obviously alongwith developent of the lesion . A significant difference was found among various groups (P < 0.05),butthere was also a considerable overlap between carcinoma and adenoma There was no corelationship between the DNA conten and AgNOR count . Conclusion: Althougb silver colloid technoque was simple , convenien and economical , the DNA aneuploidy was a possible aid in the distinction of the thyroid follicularcarcinoma from adenoma .
出处
《河南肿瘤学杂志》
1998年第4期264-266,共3页
Henan Journal of Oncology
