摘要
研究目的探讨核仁组成区嗜银蛋白(A9NOR)在鉴别滋养叶细胞肿瘤中的价值。研究背景滋养叶细胞肿瘤之间的鉴别诊断,尤其是葡萄胎与侵袭性葡萄胎之间的鉴别,长期以来一直是病理组织学上的棘手问题,本文试图以AgNOR这一定量指标来对此提供帮助。研究方法组织切片以胶质银技术染色,油镜下计数每例标本100个细胞核内的AgNOR数,求均值,以t检验进行统计学处理。研究结果葡萄胎伴滋养叶细胞轻度增生与重度增生之间,葡萄胎伴滋养叶细胞重度增生与侵袭性葡萄胎之间,以及侵袭性葡萄胎与绒癌之间AgNOR均值均有显著性差异(P<0.001)。结论 AgNOR定量可作为刮宫时鉴别良恶性葡萄胎的一项较实用指标,并可提示葡萄胎的癌前状态。
Objective The purpose of this artical is tosearch the value of AgNORs on the differentiatingtrophoblast tumors, Background The differentiating diagnosis on tl‘ophoblast tumors, especially between hyditidiform mole and invasive hyditidiform mole, has long since been a stubborn problem in histOpath010gy.We try to provide help for that with AgNORs quantitative index. M^ethOds The tissue sections were stained with silver colloid technique.The AgNORs dots of l 00 celular nuclei from each case were enumerated under an oil immersion lens,calculating average value,using,test for statistical analysis. Results A significant difl^rence was fourtd between hyditidiform mole with trophocyte mild hyperplasia and that with severe hyperplasia, hyditidiform mold with trophocyte severe。hyperplasia and invasive hyditidiform mole. invasive hyditidiform mold and chorJocarcinoma (尸<0.001). Conclusion The quantitative assay ol’ AgNORs could be used as an useful index mr t he differentiation of malignant from benign hyditidiform mole and also for the proposal of precancel’OUS state of hyditidiform mole while uterine curettage.
出处
《新乡医学院学报》
CAS
1993年第3期180-182,共3页
Journal of Xinxiang Medical University
关键词
滋养层
肿瘤
核仁组成区
鉴别诊断
trophoblastic tumor
nucleolur organizer region
differentiating diagnosis
