摘要
为探讨乳腺癌对耐药基因 P170 ,GSTPI和癌基因 ras P2 1,P5 3的表达情况 ,相关性和临床意义 ,应用 S- P免疫组化法对 40例乳腺癌切除标本进行免疫标记 ,结果显示 :乳腺癌对 4种基因的阳性表达率分别为 42 .5 % ,5 7.5 % 47.5 %和 5 2 .5 % ,耐药基因表达与乳腺癌的组织学类型无相关性 ,但在有转移的和有化疗史的乳腺癌中 ,P170和 GSTPI的阳性率 (6 6 .7% ,5 5 .6 %和73.3% ,6 6 .7% )明显高于无转移和无化疗史者 (2 8% ,31.9%和 48% ,5 0 % ) ,表明耐药基因与肿瘤复发转移的生物学行为相关 ,与癌基因 ras P2 1,P5 3间可能有相互诱导作用 ,有化疗史者阳性率增高可能系产生获得性耐药 ,因此 ,对乳腺癌化疗既要考虑本身存在的原发性耐药 ,同时术前化疗必须规范化 ,以减少继发性耐药。
Objective:To explore the expression,relativity and significance of mammary cancer to drug resistant gene P170,GSTPI and carcinomatous gene rasP21,P53.Methods:Immunolabelling was carried out for 40 cases of mammary cancer samples.Results:The positive rates were 42.5%,57.5%,47.5% and 52.5% respectively in drug resistant gene P170,GSTPI and carcinomatous gene rasP21 and P53.There was no relativity of expression of drug resistant gene with historical type of mammary cancer,and the positive rates of P170 and GSTPE (66.7%,55.6%,and 73.3%,66.7%)in the patient with the metastasis and history of chemotherapy were much more higher than the patient with neither metastasis nor history of chemotherapy (28%,31.9% and 48%,50%).These have shown that the drug resistant gene is relative with biological behavior of carcinomatous recurrent metastasis ,having a mutual induction between carcinomatous gene rasP21 and P53,and the increasement of positive rate in patient with chemotherapeutic history could develop acquired fast drug.Conclusion:Chemotherapy before operation must be in standardization to detect drug resistant gene of specimen in mammary cancer for the chemotherapy after operation.
出处
《中国肿瘤临床与康复》
1998年第4期7-9,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
乳腺癌
耐药基因
P170
GSTPI
P53
免疫组化
Mammary Cancer, Drug resistant Gene P170 GSTPI, Carcinomatous Gene rasP21 P53, Immunohistochemistry
