摘要
应用免疫组化法研究４０例膀胱移行细胞癌及６例正常膀胱粘膜标本多药耐药相关蛋白（ＭＲＰ）、Ｐ糖蛋白（Ｐｇｐ）的表达。结果：４０例膀胱肿瘤中ＭＲＰ、Ｐｇｐ的阳性率分别为５２．５％、５７．５％，其中Ｇ１、Ｇ２、Ｇ３肿瘤阳性率分别为４６．３％、３８．５％；５２．９％、３９．８％；６０．０％、８０．０％。２４例初发肿瘤标本阳性率为３７．５％、４１．７％，１６例化疗后复发肿瘤标本阳性率为７５．０％、８１．３％。结果提示ＭＲＰ、Ｐｇｐ表达量随肿瘤级别增高呈表达增强的趋势，复发病人的阳性率显著增高（Ｐ＜０．０５）。这两种蛋白的表达可能是膀胱腔内化疗失败的重要原因。
Protein product of multidrugassociated protein(MRP) and Pglycoprotein(Pgp) were detected by immunohistochemical method in 40 specimens of transition cell bladder carcinoma and in 6 normal bladder mucosa as control. MRP was positive in 21(52.5%) and Pgp being positive in 23 of 40(57.5%). In the control group, MRP was positive in 2 and Pgp positive in 1. The MRP and Pgp positive rates in grade Ⅰ,Ⅱ and Ⅲ tumors were 46.3%、38.5%,52.9%、39.8% and 60.0%、80.0%. The MRP and Pgp positive rate in primary tumor specimens were 37.5% and 41.7%, and in recurrent specimens treated by chemotherapy were 75.0% and 81.3%. The results suggested the MRP and Pgp positive rates were higher in high grade tumors and significantly higher in recurrent patients. It is probable that MRP or Pgp is one of the important factors that leads to chemotherapy failure.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1998年第7期394-396,共3页
Chinese Journal of Urology
关键词
膀胱肿瘤
药物耐受体
P-糖蛋白表达
Bladder neoplasms Carcinoma Drug tolerance Immunochemistry
