摘要
目的了解医院近5年常见病原菌分布及耐药情况,为控制医院感染提供依据。方法对医院2004年1月-2008年12月培养分离出的9318株感染病原菌的分布和耐药性进行统计与分析。结果G+球菌占13.6%,G-杆菌占28.8%,真菌占26.4%,各感染菌株数均逐年增多,真菌感染比例逐年增高;G+球菌以凝固酶阴性葡萄球菌为主,G-杆菌以大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌为主;医院感染病原菌耐药率高并有继续增高趋势,2005年出现31.8%耐亚胺培南铜绿假单胞菌,2007年出现4.0%耐万古霉素肠球菌。结论临床病原菌以G-杆菌为主,且对常用抗菌药耐药性高,临床应根据病情及时作病原菌检测,结合药敏试验结果,正确合理使用抗菌药物;真菌感染不容忽视,要加强对真菌的监测。
OBJECTIVE To investigate the distribution of commonly encountered pathogenic microbes during the last five years. METHODS A total of 9318 strains of NI pathogens during from Jan 2004 to Dee 2008 were surveyed and analyzed. RESULTS From them the percentage of Gram-positive eoeei was 13. 6%, the main pathogen was eoagulase negative Staphylococcus, Gram-negative bacilli （28. 8%）. The predominant pathogens were Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. The drug resistance of NI pathogens was markedly increased. Especially, the rate of drug resistance of P. aeruginosa to imipenem was from 0 to 31.8; in 2005, and that of Enterococcus to vancomyein was 4.0% in 2007. The percentage of fungi was 26.4% and increased sharply year by year. CONCLUSIONS The Gram-negative bacteria play a dominant role in clinics and drug resistance of isolated pathogenic bacteria is a serious problem. Monitoring the trends of pathogenic bacteria＇s distribution and drug resistance is very important in guiding the clinical administration of drugs and we should pay attention to fungal infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第22期3111-3113,共3页
Chinese Journal of Nosocomiology
关键词
医院感染
病原菌
细菌分布
耐药性
Nosoeomial infeetion
Pathogen
Bacterial distribution
Drug resistance
